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Record Contents
 
CHEMICAL IDENTIFICATION

RTECS Number KQ6300000
Chemical Name Ethyl alcohol
CAS Registry Number 64-17-5
Last Updated 201204
Data Items Cited 856
Molecular Formula C2-H6-O
Molecular Weight 46.08
Wiswesser Line Notation Q2
Compound Descriptor Tumorigen
Drug
Mutagen
Natural Product
Human
Primary Irritant
Reproductive Effector

Synonyms/Trade Names
Absolute ethanol
Aethanol
Aethylalkohol
Alcohol
Alcohol dehydrated
Alcohol, anhydrous
Alcool ethylique
Alcool etilico
Algrain
Alkohol
Alkoholu etylowego
Anhydrol
Cologne Spirit
Etanolo
Ethanol
Ethanol
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl hydrate
Ethyl hydroxide
Etylowy alkohol
Fermentation alcohol
Grain alcohol
Jaysol
Jaysol S
Methylcarbinol
Molasses alcohol
NCI-C03134
Potato alcohol
SD alcohol 23-hydrogen
Spirits of wine
Spirt
Tecsol


HEALTH HAZARD DATA


SKIN/EYE IRRITATION DATA

Type of Test Route of Exposure or Administration Species/Test System Dose Data Reaction Severity Reference
Open irritation test Administration onto the skin Rodent - rabbit 400 mg Mild UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/22/1970
Standard Draize test Administration onto the skin Rodent - rabbit 20 mg/24H Moderate 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,189,1986
Standard Draize test Administration into the eye Rodent - rabbit 500 mg Severe AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946
Standard Draize test Administration into the eye Rodent - rabbit 500 mg/24H Mild 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,189,1986
Rinsed with water Administration into the eye Rodent - rabbit 100 mg/4S Moderate FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,573,1982
Standard Draize test Administration into the eye Rodent - rabbit 100 uL Moderate HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
Standard Draize test Administration onto the skin Human 70%/2D   CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- Volume(issue)/page/year: 61,163,2009

ACUTE TOXICITY DATA

Type of Test Route of Exposure or Administration Species/Test System Dose Data Toxic Effects Reference
TDLo - Lowest published toxic dose Oral Human - man 22500 mg/kg/4W (intermittent) Endocrine - other changes Blood - other changes CLECAP Clinical Endocrinology (Oxford). (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1972- Volume(issue)/page/year: 25,143,1986
TDLo - Lowest published toxic dose Oral Human - infant 11712 uL/kg Behavioral - general anesthetic Cardiac - arrhythmias (including changes in conduction) Lungs, Thorax, or Respiration - dyspnea JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979- Volume(issue)/page/year: 9,53,1987
TDLo - Lowest published toxic dose Oral Human - woman 1200 mg/kg/3H Endocrine - changess in gonadotropins Endocrine - other changes Blood - other changes ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 7,289,1983
TDLo - Lowest published toxic dose Oral Human - man 3371 uL/kg Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Behavioral - coma VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 21,272,1979
LDLo - Lowest published lethal dose Oral Human - child 2 gm/kg Lungs, Thorax, or Respiration - other changes Liver - fatty liver degeneration Blood - other changes ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 17,183,1958
TDLo - Lowest published toxic dose Oral Human - child 14400 mg/kg/30M (intermittent) Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting APSVAM Acta Paediatrica Scandinavica. (Almqvist & Wiksell International, POB 4627, S-11691 Stockholm, Sweden) V.54-80 1965-91 For publisher information, see APAEEL Volume(issue)/page/year: 74,977,1985
LDLo - Lowest published lethal dose Oral Human 1400 mg/kg Behavioral - sleep Behavioral - headache Gastrointestinal - nausea or vomiting NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,44,1974
TDLo - Lowest published toxic dose Oral Human - man 50 mg/kg Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 56,117,1936
TDLo - Lowest published toxic dose Oral Human - man 1430 ug/kg Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - antipsychotic JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 197,488,1976
TDLo - Lowest published toxic dose Oral Human - woman 256 gm/kg/12W Behavioral - hallucinations, distorted perceptions Endocrine - effect on menstrual cycle JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 238,2143,1977
LDLo - Lowest published lethal dose Subcutaneous Human - infant 19440 mg/kg Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - body temperature decrease AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1931- Volume(issue)/page/year: 5,466,1935
LD50 - Lethal dose, 50 percent kill Oral Rodent - rat 7060 mg/kg Lungs, Thorax, or Respiration - other changes TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 16,718,1970
LC50 - Lethal concentration, 50 percent kill Inhalation Rodent - rat 20000 ppm/10H Details of toxic effects not reported other than lethal dose value NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,44,1974
LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - rat 3600 ug/kg Details of toxic effects not reported other than lethal dose value PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 2,27,1969
LD50 - Lethal dose, 50 percent kill Intravenous Rodent - rat 1440 mg/kg Lungs, Thorax, or Respiration - dyspnea TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,60,1971
LD50 - Lethal dose, 50 percent kill Intraarterial Rodent - rat 11 mg/kg Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,60,1971
LD50 - Lethal dose, 50 percent kill Oral Rodent - mouse 3450 mg/kg Details of toxic effects not reported other than lethal dose value GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(3),31,1967
LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - mouse 528 mg/kg Details of toxic effects not reported other than lethal dose value STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965
LD50 - Lethal dose, 50 percent kill Subcutaneous Rodent - mouse 8285 mg/kg Details of toxic effects not reported other than lethal dose value FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 48A,99,1970
LDLo - Lowest published lethal dose Intraperitoneal Mammal - dog 3 gm/kg Details of toxic effects not reported other than lethal dose value BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 1,207,1944
LDLo - Lowest published lethal dose Subcutaneous Mammal - dog 6 gm/kg Details of toxic effects not reported other than lethal dose value HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,130,1955
LDLo - Lowest published lethal dose Intravenous Mammal - dog 1600 mg/kg Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,60,1971
LDLo - Lowest published lethal dose Oral Mammal - cat 6 gm/kg Gastrointestinal - gastritis Liver - hepatitis (hepatocellular necrosis), diffuse Kidney/Ureter/Bladder - interstitial nephritis JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 56,117,1936
LDLo - Lowest published lethal dose Intravenous Mammal - cat 3945 mg/kg Details of toxic effects not reported other than lethal dose value HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,130,1955
LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - rabbit 963 mg/kg Details of toxic effects not reported other than lethal dose value EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
LDLo - Lowest published lethal dose Subcutaneous Rodent - rabbit 20 gm/kg Details of toxic effects not reported other than lethal dose value YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,651,1980
LD50 - Lethal dose, 50 percent kill Intravenous Rodent - rabbit 2374 mg/kg Details of toxic effects not reported other than lethal dose value EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
LCLo - Lowest published lethal concentration Inhalation Rodent - guinea pig 21900 ppm Details of toxic effects not reported other than lethal dose value FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 48A,99,1970
LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - guinea pig 3414 mg/kg Details of toxic effects not reported other than lethal dose value EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - hamster 5068 mg/kg Details of toxic effects not reported other than lethal dose value EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 61,321,1985
LDLo - Lowest published lethal dose Subcutaneous Bird - pigeon 5 gm/kg Details of toxic effects not reported other than lethal dose value FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
LDLo - Lowest published lethal dose Subcutaneous Bird - chicken 5 gm/kg Details of toxic effects not reported other than lethal dose value FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
LDLo - Lowest published lethal dose Intravenous Bird - chicken 8216 mg/kg Vascular - other changes JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 60,312,1937
LDLo - Lowest published lethal dose Subcutaneous Amphibian - frog 7100 mg/kg Details of toxic effects not reported other than lethal dose value HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 1,128,1955
LDLo - Lowest published lethal dose Parenteral Amphibian - frog 36 gm/kg Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,296,1935
LD50 - Lethal dose, 50 percent kill Intraperitoneal Mammal - species unspecified 4300 mg/kg Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 13,358,1968
TDLo - Lowest published toxic dose Oral Rodent - rat 6.4 gm/kg Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 70,17,2001
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4.2 gm/kg Nutritional and Gross Metabolic - body temperature decrease JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 293,188,2000
LCLo - Lowest published lethal concentration Inhalation Rodent - mouse 117000 mg/m3/2H Details of toxic effects not reported other than lethal dose value VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 50000 mg/m3/2H Behavioral - alteration of classical conditioning VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 2500 mg/m3/40M Brain and Coverings - other degenerative changes VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TDLo - Lowest published toxic dose Oral Rodent - rat 1500 mg/kg Behavioral - ataxia VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 12000 mg/m3/8H Behavioral - general anesthetic VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TCLo - Lowest published toxic concentration Inhalation Rodent - guinea pig 12000 mg/m3/8H Behavioral - general anesthetic VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TCLo - Lowest published toxic concentration Inhalation Rodent - rabbit 2500 mg/m3/40M Brain and Coverings - other degenerative changes VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TCLo - Lowest published toxic concentration Inhalation Human 2500 mg/m3/20M Peripheral Nerve and Sensation - recording from afferent nerve VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1984
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2.45 gm/kg Behavioral - altered sleep time (including change in righting reflex) JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 299,698,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 2.5 gm/kg Gastrointestinal - other changes AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 365,17,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 5 gm/kg Brain and Coverings - other degenerative changes Vascular - other changes Liver - other changes JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 298,737,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 8000 mg/kg Brain and Coverings - other degenerative changes Cardiac - cardiomyopathy including infarction Liver - multiple effects FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 50,52,1987
TDLo - Lowest published toxic dose Oral Rodent - rat 3 gm/kg Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 44,319,1981
TDLo - Lowest published toxic dose Oral Rodent - rat 5 gm/kg Behavioral - changes in motor activity (specific assay) FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 44,319,1981
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 3500 mg/kg Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 51,92,1988
TDLo - Lowest published toxic dose Oral Rodent - rat 6000 mg/kg Biochemical - Metabolism (Intermediary) - effect on mitochondrial function FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 55,18,1992
TDLo - Lowest published toxic dose Intravenous Human 1.6 gm/kg/6H Biochemical - Metabolism (Intermediary) - other CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960- Volume(issue)/page/year: 67,591,2000
TDLo - Lowest published toxic dose Oral Rodent - rat 4800 mg/kg Gastrointestinal - ulceration or bleeding from stomach FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 51,82,1988
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1000 mg/kg Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,38,1996
TDLo - Lowest published toxic dose Oral Rodent - rat 10 mL/kg Gastrointestinal - gastritis JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 303,1301,2002
TDLo - Lowest published toxic dose Intravenous Rodent - mouse 3 gm/kg Behavioral - sleep JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 302,257,2002
TDLo - Lowest published toxic dose Intravenous Rodent - mouse 3 gm/kg Behavioral - sleep Behavioral - tolerance JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 302,257,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 5 gm/kg Blood - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,99,2003
TDLo - Lowest published toxic dose Oral Bird - pigeon 1 gm/kg Behavioral - changes in psychophysiological tests JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 293,551,2000
TDLo - Lowest published toxic dose Oral Rodent - rat 5 mL/kg Gastrointestinal - alteration in gastric secretion Gastrointestinal - ulceration or bleeding from stomach FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 16,311,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 5 gm/kg Liver - changes in liver weight TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,98,2003
TDLo - Lowest published toxic dose Oral Primate - monkey 4.8 mg/kg Behavioral - abuse JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 301,993,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 1 gm/kg Behavioral - changes in motor activity (specific assay) Behavioral - aggression PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 157,131,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 6 gm/kg Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,202,2003
TDLo - Lowest published toxic dose Oral Human - woman 0.7 gm/kg Behavioral - changes in psychophysiological tests JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 16,379,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 5.25 gm/kg Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,128,2003
TDLo - Lowest published toxic dose Oral Rodent - mouse 4 gm/kg Endocrine - other changes Blood - changes in spleen Immunological Including Allergic - decrease in cellular immune response TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,172,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 0.5 gm/kg Behavioral - changes in psychophysiological tests EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 462,115,2003
TDLo - Lowest published toxic dose Intramuscular Non-mammalian species 0.1 gm/kg Cardiac - other changes Musculoskeletal - other changes MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 542,1,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 1600 mg/kg Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 41,1551,2003
TDLo - Lowest published toxic dose Oral Human - man 0.8 gm/kg Behavioral - euphoria Behavioral - somnolence (general depressed activity) Behavioral - changes in psychophysiological tests JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 300,236,2002
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.75 gm/kg Behavioral - ataxia PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 153,415,2001
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 0.5 gm/kg Behavioral - changes in motor activity (specific assay) NNAPBA Naunyn-Schmiedebergs Archiv fuer Pharmakologie. (Berlin, Ger.) V.264-271, 1969-71. For publisher information, see NSAPCC. Volume(issue)/page/year: 367,414,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 3000 mg/kg Behavioral - sleep TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- Volume(issue)/page/year: 73,270,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2 gm/kg Brain and Coverings - other degenerative changes Endocrine - differential effect of sex or castration on observed toxicity Biochemical - Metabolism (Intermediary) - other EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 484,241,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 0.5 gm/kg Brain and Coverings - other degenerative changes TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 133,255,2002
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1 gm/kg Sense Organs and Special Senses (Taste) - change in function PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 167,130,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4.25 gm/kg Behavioral - sleep PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,283,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2.4 mg/kg Brain and Coverings - other degenerative changes Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 169,60,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 5250 mg/kg Nutritional and Gross Metabolic - weight loss or decreased weight gain NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,451,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2 mg/kg Brain and Coverings - recordings from specific areas of CNS TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 145,69,2003
TDLo - Lowest published toxic dose Oral Human - man 0.5 gm/kg Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Endocrine - other changes NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 25,537,2001
TDLo - Lowest published toxic dose Oral Human 0.5 gm/kg Behavioral - somnolence (general depressed activity) Behavioral - changes in psychophysiological tests NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,371,2003
TDLo - Lowest published toxic dose Oral Human 1.4 gm/kg Behavioral - euphoria Behavioral - changes in psychophysiological tests Gastrointestinal - nausea or vomiting NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,740,2003
TDLo - Lowest published toxic dose Oral Human - man 0.8 gm/kg Brain and Coverings - changes in surface EEG Behavioral - changes in psychophysiological tests NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,747,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1.5 gm/kg Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,939,2003
TDLo - Lowest published toxic dose Oral Human - man 1.14 mL/kg Behavioral - changes in psychophysiological tests NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,1366,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1.25 mg/kg Behavioral - changes in motor activity (specific assay) NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 28,2124,2003
TDLo - Lowest published toxic dose Intravenous Rodent - rat 0.5 gm/kg Brain and Coverings - recordings from specific areas of CNS NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 29,530,2004
LDLo - Lowest published lethal dose Intraperitoneal Rodent - mouse 4000 mg/kg Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - body temperature decrease EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 499,285,2004
TDLo - Lowest published toxic dose Oral Human - man 0.6 gm/kg Behavioral - changes in psychophysiological tests Endocrine - other changes NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 29,1156,2004
TDLo - Lowest published toxic dose Intravenous Human - man 0.57 gm/kg Behavioral - changes in psychophysiological tests NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 29,1527,2004
LD50 - Lethal dose, 50 percent kill Oral Rodent - rat 7 gm/kg Details of toxic effects not reported other than lethal dose value USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #6696575
TDLo - Lowest published toxic dose Oral Primate - monkey 102 mg/kg Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,1,2003
TDLo - Lowest published toxic dose Intracerebral Rodent - rat 363.6 ug/kg Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,51,2003
TDLo - Lowest published toxic dose Multiple routes Human - man 3660 mg/kg Endocrine - evidence of thyroid hypofunction PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,213,2003
TDLo - Lowest published toxic dose Intracerebral Rodent - rat 106 ug/kg Behavioral - changes in motor activity (specific assay) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 170,368,2003
TDLo - Lowest published toxic dose Intravenous Human 0.89 mL/kg Vascular - regional or general arteriolar constriction Vascular - measurement of regional blood flow JKMSEH Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- Volume(issue)/page/year: 19,51,2004
TDLo - Lowest published toxic dose Intraarterial Human - man 0.071 mL/kg Vascular - acute arterial occlusion JKMSEH Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- Volume(issue)/page/year: 18,585,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 3 gm/kg Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 197,206,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 500 mg/kg Behavioral - analgesia PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 171,204,2004
TDLo - Lowest published toxic dose Oral Human 400 mg/kg Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 172,68,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 1000 mg/kg Behavioral - aggression PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 172,255,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 5000 mg/kg Endocrine - other changes Blood - changes in other cell count (unspecified) TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 5000 mg/kg Endocrine - other changes Blood - changes in other cell count (unspecified) TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 6000 mg/kg Blood - changes in spleen TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 5000 mg/kg Immunological Including Allergic - decrease in cellular immune response TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
TDLo - Lowest published toxic dose Oral Mammal - species unspecified 4000 mg/kg Endocrine - other changes Immunological Including Allergic - decrease in humoral immune response TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 5000 mg/kg Liver - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,213,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 1500 mg/kg Behavioral - alteration of classical conditioning TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,224,2005
TDLo - Lowest published toxic dose Unreported Rodent - rat 3 gm/kg Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - other proteins TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 150,325,2004
TDLo - Lowest published toxic dose Subcutaneous Rodent - mouse 5 gm/kg Liver - hepatitis (hepatocellular necrosis), zonal TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,119,2002
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 0.25 gm/kg Behavioral - alteration of operant conditioning JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 17,293,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 0.5 gm/kg Behavioral - changes in motor activity (specific assay) Behavioral - alteration of operant conditioning JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 17,293,2003
TDLo - Lowest published toxic dose Oral Human 0.5 mg/kg Behavioral - changes in psychophysiological tests JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 17,379,2003
TDLo - Lowest published toxic dose Oral Rodent - mouse 6000 mg/kg Immunological Including Allergic - decrease in cellular immune response TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,28,2001
TDLo - Lowest published toxic dose Oral Mammal - dog 2 gm/kg Behavioral - changes in psychophysiological tests TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 66,263,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 5 gm/kg Behavioral - anticonvulsant ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 79,610,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 0.72 gm/kg Behavioral - abuse Endocrine - differential effect of sex or castration on observed toxicity BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 37,1511,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.5 mg/kg Behavioral - antianxiety PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 177,84,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2 gm/kg Behavioral - alteration of operant conditioning Behavioral - changes in psychophysiological tests PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 176,166,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2.5 gm/kg Behavioral - somnolence (general depressed activity) Behavioral - alteration of operant conditioning Behavioral - changes in psychophysiological tests PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 176,166,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 10.5 gm/kg/2H Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - other TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,380,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4 gm/kg Behavioral - somnolence (general depressed activity) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,358,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 6 gm/kg Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 175,189,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2 mg/kg Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,291,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1 gm/kg Behavioral - antianxiety Behavioral - changes in psychophysiological tests HOBEAO Hormones and Behavior. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 49,123,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1000 mg/kg Liver - other changes MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 577S,1,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 0.25 gm/kg Behavioral - analgesia JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 309,86,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 5000 mg/kg Behavioral - general anesthetic TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 6000 mg/kg Behavioral - changes in psychophysiological tests TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2 gm/kg Behavioral - changes in psychophysiological tests JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 314,675,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1000 mg/kg Behavioral - food intake (animal) EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 519,96,2005
TDLo - Lowest published toxic dose Oral Human 0.7 gm/kg/10M Behavioral - changes in psychophysiological tests JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 19,627,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 1.5 mg/kg Behavioral - alteration of classical conditioning ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000- Volume(issue)/page/year: 24,1137,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2000 mg/kg Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - other EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 520,51,2005
TDLo - Lowest published toxic dose Oral Human - man 625 mg/kg Cardiac - pulse rate Cardiac - change in rate Nutritional and Gross Metabolic - body temperature increase ECPPH* Experimental and Clinical Psychopharmacology (Washington Dc American Psychological Association) V.1- 1993- Volume(issue)/page/year: 2,53,1994
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4 gm/kg Behavioral - withdrawal JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 319,219,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2.0 gm/kg Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 319,219,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2 gm/kg Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 319,1366,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 4 mL/kg Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 29,1973,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 10 mL/kg Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - other changes BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 29,2206,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 10 mL/kg Gastrointestinal - other changes BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 29,2206,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 4300 mg/kg Vascular - measurement of regional blood flow TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 235,141,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 6000 mg/kg Biochemical - Metabolism (Intermediary) - other TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 235,141,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 500 mg/kg Liver - other changes Biochemical - Metabolism (Intermediary) - other TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 223,225,2007
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 4930 mg/m3 Details of toxic effects not reported other than lethal dose value TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 1110 mg/m3/4H Details of toxic effects not reported other than lethal dose value TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
TDLo - Lowest published toxic dose Oral Human 600 mg/kg Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 42,761,2004
LD50 - Lethal dose, 50 percent kill Intravenous Rodent - mouse 1973 mg/kg Details of toxic effects not reported other than lethal dose value ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 Volume(issue)/page/year: ,706,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1000 mg/kg Behavioral - muscle weakness NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 27,1064,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2000 mg/kg Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - alteration of operant conditioning NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 27,1064,2006
TDLo - Lowest published toxic dose Oral Human - man 650 mg/kg Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - alteration of operant conditioning NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 27,1064,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 500 mg/kg Behavioral - alteration of classical conditioning NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 3000 mg/kg Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 169,253,2007
TDLo - Lowest published toxic dose Oral Human 0.1 gm/kg Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 369(Suppl 1),R106,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.5 gm/kg Behavioral - changes in motor activity (specific assay) Behavioral - antianxiety PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,311,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2 gm/kg Behavioral - ataxia Behavioral - alteration of classical conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,311,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 3.5 gm/kg Behavioral - altered sleep time (including change in righting reflex) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,311,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 0.4 gm/kg Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,679,2007
TDLo - Lowest published toxic dose Intravenous Human - man 0.571 gm/kg Brain and Coverings - other degenerative changes PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,975,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 0.3 mg/kg Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.2 mg/kg Behavioral - changes in motor activity (specific assay) Behavioral - antianxiety Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.8 mg/kg Behavioral - alteration of classical conditioning Behavioral - antianxiety Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
TDLo - Lowest published toxic dose Oral Human - man 0.45 gm/kg Behavioral - changes in psychophysiological tests ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 4,293,1987
TDLo - Lowest published toxic dose Intravenous Rodent - rabbit 0.8 gm/kg Brain and Coverings - changes in surface EEG PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 57,61,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 4.44 mL/kg Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - other changes Biochemical - Metabolism (Intermediary) - lipids including transport PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 57,481,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2 gm/kg Brain and Coverings - recordings from specific areas of CNS Behavioral - anticonvulsant JPHPH* Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. (Krakow Polish Physiological Society) V.42- 2001- Volume(issue)/page/year: 58,641,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 3 gm/kg Behavioral - sleep JPHSC* Journal of pharmacological sciences (Kyoto, Japan : Japanese Pharmacological Society) V.91- 2003- Volume(issue)/page/year: 106,361,2008
TDLo - Lowest published toxic dose Intravenous Rodent - rabbit 0.8 gm/kg Brain and Coverings - changes in surface EEG Behavioral - ataxia PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 58,890,2006
LDLo - Lowest published lethal dose Unreported Rodent - mouse 2 gm/kg Details of toxic effects not reported other than lethal dose value JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 4 gm/kg Immunological Including Allergic - decreased immune response Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,276,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2 gm/kg Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1739,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 12800 mg/kg Gastrointestinal - ulceration or bleeding from stomach Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 47,134,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 4.8 gm/kg Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - effect on mitochondrial function TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 252,86,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 2 gm/kg Behavioral - altered sleep time (including change in righting reflex) BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 41,782,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 6.45 mL/kg Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - other changes Biochemical - Metabolism (Intermediary) - lipids including transport BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 31,1351,2008
LD50 - Lethal dose, 50 percent kill Oral Rodent - rat 15010 mg/kg Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - gastritis HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LDLo - Lowest published lethal dose Oral Rodent - rat 7000 mg/kg Lungs, Thorax, or Respiration - respiratory depression HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LD50 - Lethal dose, 50 percent kill Oral Rodent - rabbit 6300 mg/kg Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LDLo - Lowest published lethal dose Oral Mammal - cat 6000 mg/kg Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LDLo - Lowest published lethal dose Oral Mammal - dog 5500 mg/kg Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LD50 - Lethal dose, 50 percent kill Oral Rodent - guinea pig 5560 mg/kg Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LC50 - Lethal concentration, 50 percent kill Inhalation Rodent - mouse >60000 ppm/1H Behavioral - ataxia HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 13300 ppm/1.33H Behavioral - ataxia HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 23940 ppm/1.25H Behavioral - general anesthetic HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LCLo - Lowest published lethal concentration Inhalation Rodent - mouse 29300 ppm/7H Behavioral - general anesthetic HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 31900 ppm/0.33H Behavioral - ataxia HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LC50 - Lethal concentration, 50 percent kill Inhalation Rodent - rat 5900 mg/m3/6H Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LC50 - Lethal concentration, 50 percent kill Inhalation Rodent - rat 124700 mg/m3/4H Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - guinea pig 12850 ppm/8.75H Behavioral - general anesthetic HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LCLo - Lowest published lethal concentration Inhalation Rodent - guinea pig 21900 ppm/9.8H Behavioral - general anesthetic HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LC50 - Lethal concentration, 50 percent kill Inhalation Rodent - mouse 39000 mg/m3/4H Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Human 1800 ppm/30M Lungs, Thorax, or Respiration - bronchiolar constriction Lungs, Thorax, or Respiration - cough HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
LDLo - Lowest published lethal dose Administration onto the skin Rodent - rabbit 20000 mg/kg Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Subcutaneous Rodent - rat 7900 mg/kg Reproductive - Maternal Effects - menstrual cycle changes or disorders HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2500 mg/kg Endocrine - changes in luteinizing hormone Endocrine - androgenic Reproductive - Paternal Effects - testes, epididymis, sperm duct HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 1000 mg/kg Behavioral - alteration of operant conditioning PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 89,179,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 3.08 mL/kg Gastrointestinal - ulceration or bleeding from stomach PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 9,125,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 4.57 mL/kg Gastrointestinal - ulceration or bleeding from stomach Biochemical - Metabolism (Intermediary) - other PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 9,515,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 6000 mg/kg Liver - other changes Biochemical - Metabolism (Intermediary) - effect on mitochondrial function TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,237,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 4.8 mL/kg Gastrointestinal - ulceration or bleeding from stomach Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Metabolism (Intermediary) - effect on active transport PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 12,264,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.5 gm/kg Behavioral - alteration of classical conditioning PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 15,587,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4.4 gm/kg Brain and Coverings - other degenerative changes NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,459,2009
LD50 - Lethal dose, 50 percent kill Oral Rodent - mouse 10.5 mL/kg Details of toxic effects not reported other than lethal dose value HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
LD50 - Lethal dose, 50 percent kill Intravenous Rodent - mouse 2.8 mL/kg Details of toxic effects not reported other than lethal dose value HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
LD50 - Lethal dose, 50 percent kill Intraperitoneal Rodent - mouse 4 mL/kg Details of toxic effects not reported other than lethal dose value HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
LC50 - Lethal concentration, 50 percent kill Inhalation Rodent - mouse >40000 ppm/10M Behavioral - ataxia HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1500 mg/kg Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 197,67,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2800 mg/kg Brain and Coverings - other degenerative changes PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 201,261,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 1.5 mg/kg Behavioral - alteration of classical conditioning Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 200,105,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 1000 mg/kg Nutritional and Gross Metabolic - body temperature decrease PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 197,409,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 3 gm/kg Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 322,1003,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 1 gm/kg Cardiac - change in rate Cardiac - cardiac output Vascular - BP lowering not characterized in autonomic section JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 324,368,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2700 mg/kg Behavioral - ataxia PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 194,139,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 3.9 gm/kg Gastrointestinal - gastritis Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 579,214,2005
TCLo - Lowest published toxic concentration Multiple routes Non-mammalian species 1 pph/30M Behavioral - changes in motor activity (specific assay) NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,84,2010
TDLo - Lowest published toxic dose Intravenous Mammal - cat 2 gm/kg Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - effect, not otherwise specified TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 243,348,2010
TDLo - Lowest published toxic dose Intravenous Rodent - rat 0.72 gm/kg/10M Spinal Cord - other degenerative changes Vascular - BP lowering not characterized in autonomic section BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 158,806,2009
TDLo - Lowest published toxic dose Intravenous Rodent - rat 1.03 gm/kg/40M Spinal Cord - other degenerative changes Behavioral - tolerance BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 158,806,2009
LCLo - Lowest published lethal concentration Chemical added to tank with water (dissolved in water) Fish - zebrafish 1 gm/L/144H Details of toxic effects not reported other than lethal dose value TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 102,162,2011
TCLo - Lowest published toxic concentration Chemical added to tank with water (dissolved in water) Fish - zebrafish 0.01 gm/L/144H Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 102,162,2011
ICLo - Inhibitor Concentration Low In vitro Mouse - fibroblast >428.2 mmol/L/24H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
ICLo - Inhibitor Concentration Low In vitro Mouse - macrophage >513 mmol/L/24H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
ICLo - Inhibitor Concentration Low In vitro Hamster - lung fibroblast >478.8 mmol/L/24H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
ICLo - Inhibitor Concentration Low In vitro Human - liver tumor >428.2 mmol/L/24H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 1,3,1987
IC50 - Inhibitor Concentration 50 In vitro Human - liver tumor 716 mmol/L/24H In Vitro Toxicity Studies - cell protein synthesis TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 3,189,1989
IC50 - Inhibitor Concentration 50 In vitro Rabbit - ocular 0.06 gm/L/10M In Vitro Toxicity Studies - cell viability (cell death), unspecified assay TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 3,329,1989
ICLo - Inhibitor Concentration Low In vitro Human - lung fibroblast 0.1 gm/L/7D In Vitro Toxicity Studies - cell proliferation: DNA incorporation, mitotic index etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,1,1990
IC50 - Inhibitor Concentration 50 In vitro Mouse - liver 1372 mmol/L/2H Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 4,783,1990
IC50 - Inhibitor Concentration 50 In vitro Rat - liver >39450 mg/L/20H In Vitro Toxicity Studies - cell membrane integrity: cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver >39450 mg/L/20H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver >39450 mg/L/20H In Vitro Toxicity Studies - cell protein synthesis TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver >39450 mg/L/20H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver tumor >39450 mg/L/20H In Vitro Toxicity Studies - cell membrane integrity: cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver tumor >39450 mg/L/20H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver tumor >33450 mg/L/20H In Vitro Toxicity Studies - cell protein synthesis TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Rat - liver tumor >39450 mg/L/20H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,543,1991
IC50 - Inhibitor Concentration 50 In vitro Human - liver 303 umol/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
IC10 - Inhibitor Concentration 10 In vitro Human - liver 126 umol/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
IC50 - Inhibitor Concentration 50 In vitro Rat - liver 620 umol/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
IC10 - Inhibitor Concentration 10 In vitro Rat - liver 174 umol/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
IC50 - Inhibitor Concentration 50 In vitro Mouse - fibroblast 854 umol/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
IC10 - Inhibitor Concentration 10 In vitro Mouse - fibroblast 521 umol/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992
IC50 - Inhibitor Concentration 50 In vitro Human - skin 29000 mg/L/48H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,367,1992
IC50 - Inhibitor Concentration 50 In vitro Human - skin 139000 mg/L/1M In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,367,1992
IC50 - Inhibitor Concentration 50 In vitro Rat - lung 3.8 gm/L/24H In Vitro Toxicity Studies - cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
IC50 - Inhibitor Concentration 50 In vitro Rat - lung 12.9 gm/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
IC10 - Inhibitor Concentration 10 In vitro Rat - lung 0.26 gm/L/24H In Vitro Toxicity Studies - cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
IC75 - Inhibitor Concentration 75 In vitro Rat - lung 20 gm/L/24H In Vitro Toxicity Studies - cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
IC10 - Inhibitor Concentration 10 In vitro Rat - lung 0.62 gm/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
IC75 - Inhibitor Concentration 75 In vitro Rat - lung 85.1 gm/L/24H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,111,1993
IC50 - Inhibitor Concentration 50 In vitro Hamster - lung fibroblast 147.5 mmol/L/60H In Vitro Toxicity Studies - cell counting TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
IC10 - Inhibitor Concentration 10 In vitro Hamster - lung fibroblast 16 mmol/L/60H In Vitro Toxicity Studies - cell counting TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
IC50 - Inhibitor Concentration 50 In vitro Human - HeLa cell 157.5 mmol/L/60H In Vitro Toxicity Studies - cell counting TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
IC10 - Inhibitor Concentration 10 In vitro Human - HeLa cell 48 mmol/L/60H In Vitro Toxicity Studies - cell counting TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,511,1993
IC50 - Inhibitor Concentration 50 In vitro Non-mammalian species - fibroblast 254 mmol/L/24H In Vitro Toxicity Studies - cell counting TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,537,1993
IC50 - Inhibitor Concentration 50 In vitro Chicken - neurons 200422 umol/L/21H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
IC10 - Inhibitor Concentration 10 In vitro Chicken - neurons 16072 umol/L/21H In Vitro Toxicity Studies - cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
IC50 - Inhibitor Concentration 50 In vitro Chicken - neurons 134186 umol/L/20H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
IC10 - Inhibitor Concentration 10 In vitro Chicken - neurons 28898 umol/L/20H In Vitro Toxicity Studies - cell viability (lysosomal damage): neutral red assay etc. TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 7,653,1993
TDLo - Lowest published toxic dose Oral Rodent - rat 2.375 mL/kg Gastrointestinal - ulceration or bleeding from stomach JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 134,904,2011
LC - Lethal concentration Inhalation Rodent - rat >29430 mg/m3/7H Details of toxic effects not reported other than lethal dose value HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008

OTHER MULTIPLE DOSE TOXICITY DATA

Type of Test Route of Exposure or Administration Species/Test System Dose Data Toxic Effects Reference
TDLo - Lowest published toxic dose Oral Rodent - rat 1825 gm/kg/1Y (continuous) Liver - fatty liver degeneration Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain DDSCDJ Digestive Diseases and Sciences. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.24- 1979- Volume(issue)/page/year: 25,587,1980
TDLo - Lowest published toxic dose Oral Rodent - rat 19 gm/kg/21D (continuous) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 12,265,1982
TDLo - Lowest published toxic dose Oral Rodent - rat 280 gm/kg/5W (intermittent) Cardiac - changes in heart weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in testicular weight JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,243,1983
TDLo - Lowest published toxic dose Oral Rodent - rat 851 gm/kg/10W (continuous) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 38,260,1976
TDLo - Lowest published toxic dose Oral Rodent - rat 7 mL/kg/7D (intermittent) Liver - other changes Biochemical - Effect on specific coenzyme - B vitamins including folate JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 10(1-2),25,1978
TDLo - Lowest published toxic dose Oral Rodent - rat 6300 mg/kg/9W (intermittent) Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 64(1),46,1999
TDLo - Lowest published toxic dose Oral Mammal - dog 560 mL/kg/10W (continuous) Brain and Coverings - other degenerative changes Cardiac - other changes Liver - other changes PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 128,1021,1968
TDLo - Lowest published toxic dose Oral Primate - monkey 210 gm/kg/5W (intermittent) Liver - fatty liver degeneration JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,243,1983
TDLo - Lowest published toxic dose Oral Rodent - rat 45 gm/kg/30D (intermittent) Behavioral - changes in psychophysiological tests GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: -,64,1993
TDLo - Lowest published toxic dose Oral Rodent - mouse 3500 gm/kg/10W (continuous) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 225,479,1983
TDLo - Lowest published toxic dose Oral Rodent - mouse 2100 gm/kg/5W (continuous) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 225,479,1983
TDLo - Lowest published toxic dose Oral Rodent - mouse 1750 gm/kg/5W (continuous) Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 225,479,1983
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 8000 mg/m3/4H/17W (intermittent) Brain and Coverings - other degenerative changes Endocrine - other changes Immunological Including Allergic - decreased immune response VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1994
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 8000 mg/m3/4H/17W (intermittent) Brain and Coverings - other degenerative changes Endocrine - other changes Immunological Including Allergic - decreased immune response VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1994
TCLo - Lowest published toxic concentration Inhalation Rodent - rabbit 8000 mg/m3/4H/17W (intermittent) Brain and Coverings - other degenerative changes Endocrine - other changes Immunological Including Allergic - decreased immune response VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,93,1994
TDLo - Lowest published toxic dose Oral Rodent - rat 62.5 gm/kg/5D (continuous) Brain and Coverings - other degenerative changes Endocrine - effect on menstrual cycle Endocrine - changess in gonadotropins BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,1089,1987
TDLo - Lowest published toxic dose Oral Rodent - rat 62.5 gm/kg/6D (continuous) Endocrine - effect on menstrual cycle BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,1089,1987
TDLo - Lowest published toxic dose Oral Rodent - mouse 448 gm/kg/4W (continuous) Behavioral - fluid intake NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
TDLo - Lowest published toxic dose Oral Rodent - rat 65 gm/kg/13D (continuous) Endocrine - other changes ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 138,389,1997
TDLo - Lowest published toxic dose Oral Rodent - rat 900 mL/kg/62D (continuous) Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 24,275,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 240000 mg/kg/30D (intermittent) Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 47,82,1984
TDLo - Lowest published toxic dose Intramuscular Rodent - rat 420 gm/kg/6W (intermittent) Liver - hepatitis (hepatocellular necrosis), diffuse Liver - fatty liver degeneration Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 299,832,2001
TDLo - Lowest published toxic dose Intramuscular Rodent - mouse 42 gm/kg/14D (intermittent) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Liver - other changes FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 46,103,1983
TDLo - Lowest published toxic dose Intramuscular Rodent - mouse 63 gm/kg/21D (intermittent) Liver - fatty liver degeneration Liver - liver function tests impaired FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 46,103,1983
TDLo - Lowest published toxic dose Oral Rodent - rat 35000 mg/kg/7D (intermittent) Nutritional and Gross Metabolic - weight loss or decreased weight gain EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
TDLo - Lowest published toxic dose Oral Rodent - rat 115000 mg/kg/23D (intermittent) Behavioral - alteration of classical conditioning EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
TDLo - Lowest published toxic dose Oral Rodent - rat 67.5 mg/kg/15D (continuous) Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - xanthine, purine or nucleotides including urate Biochemical - Metabolism (Intermediary) - other proteins JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 296,857,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 93.8 mL/kg/2W (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Biochemical - Metabolism (Intermediary) - lipids including transport JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 22,207,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 882 gm/kg/75D (intermittent) Musculoskeletal - other changes JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 301,1132,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 72 gm/kg/7D (continuous) Kidney/Ureter/Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,315,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 908 mg/kg/4W (continuous) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 22,207,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 1372 gm/kg/20W (continuous) Behavioral - food intake (animal) Vascular - regional or general arteriolar constriction Vascular - other changes CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- Volume(issue)/page/year: 29,707,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 24000 mL/kg/120D (continuous) Kidney/Ureter/Bladder - other changes in urine composition TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,195,2003
TDLo - Lowest published toxic dose Oral Rodent - mouse 36000 mL/kg/180D (continuous) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,195,2003
TDLo - Lowest published toxic dose Oral Rodent - mouse 36000 mL/kg/180D (continuous) Liver - other changes Nutritional and Gross Metabolic - changes in iron Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,195,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 8 mg/kg/4D (intermittent) Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - other proteins TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,127,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 9660 gm/kg/56W (intermittent) Cardiac - change in resting or action potential Endocrine - differential effect of sex or castration on observed toxicity Nutritional and Gross Metabolic - weight loss or decreased weight gain TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 189,196,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 240 gm/kg/60D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 42,367,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 12 gm/kg/20D (continuous) Behavioral - tolerance Behavioral - alteration of operant conditioning EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 477,129,2003
TDLo - Lowest published toxic dose Oral Primate - monkey 260 gm/kg/2Y (intermittent) Behavioral - alteration of classical conditioning Behavioral - aggression PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 165,1,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 210 gm/kg/10W (continuous) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 41,1551,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 4500 gm/kg/24W (intermittent) Behavioral - food intake (animal) Cardiac - change in force of contraction Endocrine - differential effect of sex or castration on observed toxicity TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 179,111,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 84 gm/kg/4W (intermittent) Behavioral - food intake (animal) Endocrine - other changes Nutritional and Gross Metabolic - other changes BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 36,125,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 14 gm/kg/7D (intermittent) Brain and Coverings - other degenerative changes BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 36,503,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 28 gm/kg/7D (intermittent) Brain and Coverings - other degenerative changes Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 36,503,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 4.8 mg/kg/4D (intermittent) Behavioral - changes in motor activity (specific assay) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 160,48,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 875 mg/kg/10W (intermittent) Kidney/Ureter/Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Biochemical - Metabolism (Intermediary) - effect on Sodium-Potassium pump LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 71,2881,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 1120 gm/kg/4W (intermittent) Blood - changes in spleen Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- Volume(issue)/page/year: 73,72,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 41.6 gm/kg/4D (continuous) Behavioral - analgesia LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 73,3351,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 130 gm/kg/10D (continuous) Behavioral - tolerance Behavioral - withdrawal LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 73,3351,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 36000 mg/kg/6D (continuous) Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning Behavioral - alteration of operant conditioning NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,35,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 8 gm/kg/10D (intermittent) Behavioral - abuse PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 168,208,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 300 gm/kg/12W (intermittent) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 42,429,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 27000 mg/kg/6D (intermittent) Brain and Coverings - other degenerative changes NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,353,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 31500 mg/kg/6D (intermittent) Cardiac - change in rate NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,451,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 12 mg/kg/3D (intermittent) Behavioral - alteration of classical conditioning BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 138,9,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 21000 mg/kg/7D (intermittent) Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 138,1376,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 15 gm/kg/15D (intermittent) Endocrine - androgenic REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,641,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 30 gm/kg/15D (intermittent) Endocrine - estrogenic REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,641,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 90 gm/kg/15D (intermittent) Reproductive - Paternal Effects - testes, epididymis, sperm duct REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,641,2003
TDLo - Lowest published toxic dose Oral Human - man 4623 gm/kg/12Y (intermittent) Brain and Coverings - other degenerative changes DADEDV Drug and Alcohol Dependence. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 65,159,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 108 gm/kg/4W (intermittent) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Liver - other changes FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 42,2045,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 10400 mg/kg/13D (intermittent) Endocrine - estrogenic BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 90,2225,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 98800 mg/kg/13D (continuous) Behavioral - withdrawal Behavioral - alteration of classical conditioning EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 499,285,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 875 gm/kg/35D (continuous) Liver - liver function tests impaired TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 197,206,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 42 gm/kg/7D (intermittent) Behavioral - changes in psychophysiological tests NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,55,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 25000 mg/kg/5D (intermittent) Behavioral - alteration of operant conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 171,204,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 420 gm/kg/10W (intermittent) Brain and Coverings - other degenerative changes Musculoskeletal - other changes Biochemical - Metabolism (Intermediary) - lipids including transport TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 199,161,2004
TDLo - Lowest published toxic dose Oral Mammal - species unspecified 112000 mg/kg/28D (intermittent) Immunological Including Allergic - decrease in cellular immune response TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,184,2005
TDLo - Lowest published toxic dose Parenteral Rodent - rat 50000 mg/kg/50D (intermittent) Liver - hepatitis (hepatocellular necrosis), zonal Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,15,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 48000 mg/kg/12W (intermittent) Cardiac - other changes Vascular - BP elevation not characterized in autonomic section Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,46,2005
TDLo - Lowest published toxic dose Oral Rodent - hamster 512 mg/kg/30D (continuous) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8. Volume(issue)/page/year: 129,285,2001
TDLo - Lowest published toxic dose Oral Rodent - hamster 559 mg/kg/30D (continuous) Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8. Volume(issue)/page/year: 129,285,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 6650 mL/kg/10W (continuous) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8. Volume(issue)/page/year: 131,161,2002
TDLo - Lowest published toxic dose Oral Rodent - mouse 480000 mg/kg/60D (continuous) Gastrointestinal - changes in structure or function of endocrine pancreas TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,318,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 396 gm/kg/198D (continuous) Liver - other changes Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,14,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 396 gm/kg/198D (continuous) Liver - other changes Nutritional and Gross Metabolic - changes in iron Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,14,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 273000 mg/kg/21D (continuous) Musculoskeletal - osteoporosis TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,354,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 1428000 mg/kg/14D (continuous) Behavioral - fluid intake Liver - other changes Nutritional and Gross Metabolic - conditioned vitamin deficiency DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 26,191,2003
TDLo - Lowest published toxic dose Oral Rodent - mouse 295.2 gm/kg/10W (intermittent) Cardiac - cardiomyopathy including infarction Cardiac - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,167,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 168 gm/kg/12W (intermittent) Cardiac - other changes Vascular - BP elevation not characterized in autonomic section Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,168,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 270 gm/kg/90D (intermittent) Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Biochemical - Metabolism (Intermediary) - other proteins ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 78,276,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 54 gm/kg/9D (intermittent) Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,280,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 54 gm/kg/9D (intermittent) Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal - osteoporosis TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,280,2004
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 6130 ppm/4W (intermittent) Endocrine - changes in thymus weight JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 25,193,2005
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 6130 ppm/4W (intermittent) Brain and Coverings - other degenerative changes Cardiac - changes in heart weight Endocrine - hyperglycemia JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 25,193,2005
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 6130 ppm/4W (intermittent) Biochemical - Metabolism (Intermediary) - other JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 25,193,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 15000 mg/kg/2D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - other TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,41,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 60 gm/kg/30D (intermittent) Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS Biochemical - Neurotransmitters or modulators (putative) - dopamine in striatum BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 37,1839,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4 gm/kg/8D (intermittent) Behavioral - alteration of classical conditioning Behavioral - changes in psychophysiological tests PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 176,50,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 50 gm/kg/10D (intermittent) Liver - other changes Biochemical - Metabolism (Intermediary) - other PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 182,58,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 600000 mg/kg/75D (intermittent) Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in calcium TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,388,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 354000 mg/kg/30D (intermittent) Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in calcium TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,388,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 462000 mg/kg/6W (intermittent) Musculoskeletal - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 60,388,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 31.5 gm/kg/6D (intermittent) Behavioral - changes in psychophysiological tests Nutritional and Gross Metabolic - weight loss or decreased weight gain NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,815,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 35 gm/kg/5W (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other proteins TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 215,234,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 126 gm/kg/12W (continuous) Vascular - BP lowering not characterized in autonomic section JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 306,271,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 400 gm/kg/8W (intermittent) Brain and Coverings - recordings from specific areas of CNS Behavioral - withdrawal JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 307,566,2003
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 204 gm/kg/68D (continuous) Reproductive - Maternal Effects - other effects JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 308,644,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 52800 mg/kg/6D (intermittent) Behavioral - convulsions or effect on seizure threshold Behavioral - withdrawal Gastrointestinal - other changes TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 52800 mg/kg/6D (intermittent) Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 52800 mg/kg/6D (intermittent) Related to Chronic Data - death TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 30 gm/kg/3D (continuous) Biochemical - Effect on specific coenzyme - proportion of isoenzymes Liver - other changes ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000- Volume(issue)/page/year: 24,831,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 195 gm/kg/30D (continuous) Brain and Coverings - other degenerative changes ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000- Volume(issue)/page/year: 24,930,2003
TDLo - Lowest published toxic dose Oral Rodent - mouse 95200 mg/kg/4W (intermittent) Behavioral - food intake (animal) Behavioral - fluid intake NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
TDLo - Lowest published toxic dose Oral Rodent - mouse 78400 mg/kg/4W (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
TDLo - Lowest published toxic dose Oral Rodent - mouse 496000 mg/kg/80W (intermittent) Nutritional and Gross Metabolic - weight loss or decreased weight gain NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
TDLo - Lowest published toxic dose Oral Rodent - mouse 2920000 mg/kg/2Y (intermittent) Liver - other changes Liver - tumors Liver - changes in liver weight NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
TDLo - Lowest published toxic dose Oral Rodent - mouse 5256000 mg/kg/2Y (intermittent) Liver - tumors NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: TR-510
- Subcutaneous Rodent - mouse 5000 mg/kg/20D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 44,588,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 420000 mg/kg/12W (intermittent) Liver - other changes Kidney/Ureter/Bladder - other changes in urine composition Kidney/Ureter/Bladder - other changes TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 219,11,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 210 gm/kg/6W (intermittent) Nutritional and Gross Metabolic - weight loss or decreased weight gain Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 27,1636,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 470220 mg/kg/51D (continuous) Musculoskeletal - osteoporosis TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 220,302,2007
TDLo - Lowest published toxic dose Oral Human 149 units/kg/4Y (intermittent) Skin and Appendages - dermatitis, other (after systemic exposure) BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 155,195,2006
TDLo - Lowest published toxic dose Oral Rodent - mouse 284.4 gm/kg/45D (intermittent) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 22,149,2003
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 4930 mg/m3/4D (intermittent) Peripheral Nerve and Sensation - recording from peripheral motor nerve Lungs, Thorax, or Respiration - other changes TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 4930 mg/m3/8D (intermittent) Behavioral - alteration of classical conditioning TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 4930 mg/m3/14D (intermittent) Behavioral - changes in motor activity (specific assay) TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 1110 mg/m3/14D (intermittent) Vascular - other changes TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,76,1979
TDLo - Lowest published toxic dose Oral Rodent - rat 50.4 gm/kg/7D (continuous) Brain and Coverings - other degenerative changes Behavioral - abuse BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 143,455,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 300000 mg/kg/12W (intermittent) Liver - other changes Kidney/Ureter/Bladder - other changes Nutritional and Gross Metabolic - conditioned vitamin deficiency FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 45,1478,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 216000 mg/kg/90D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 45,1333,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 84 gm/kg/5W (continuous) Cardiac - cardiomyopathy including infarction Cardiac - other changes Cardiac - changes in heart weight NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 375(Suppl 1),60,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 84 gm/kg/5W (continuous) Vascular - relaxation (isolated tissues) NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 375(Suppl 1),60,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 7000 mg/kg/7D (intermittent) Behavioral - changes in psychophysiological tests Nutritional and Gross Metabolic - weight loss or decreased weight gain NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 7000 mg/kg/7D (intermittent) Behavioral - changes in psychophysiological tests NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 7000 mg/kg/7D (intermittent) Behavioral - tolerance Behavioral - changes in psychophysiological tests NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,23,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 315 gm/kg/9W (intermittent) Vascular - BP elevation not characterized in autonomic section Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974- Volume(issue)/page/year: 33,183,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 151.2 gm/kg/21D (intermittent) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - abuse FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 18,693,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 284.4 gm/kg/45D (intermittent) Liver - hepatitis (hepatocellular necrosis), diffuse Endocrine - other changes Biochemical - Metabolism (Intermediary) - lipids including transport FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 20,129,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 3 gm/kg/3D (intermittent) Behavioral - alteration of classical conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 191,909,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 37.8 mg/kg/21D (intermittent) Behavioral - changes in motor activity (specific assay) Behavioral - tolerance Behavioral - alteration of classical conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 12.6 mg/kg/21D (intermittent) Behavioral - tolerance PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,39,2007
TDLo - Lowest published toxic dose Oral Primate - monkey 32.5 gm/kg/90D (intermittent) Cardiac - change in rate PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 192,183,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 980 gm/kg/14W (intermittent) Behavioral - food intake (animal) Cardiac - cardiac output Kidney/Ureter/Bladder - changes in blood vessels or in circulation of kidney JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998- Volume(issue)/page/year: 68,797,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 1050 gm/kg/70D (intermittent) Liver - other changes Biochemical - Metabolism (Intermediary) - other proteins ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 41,591,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 188 gm/kg/25D (intermittent) Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Biochemical - Metabolism (Intermediary) - lipids including transport INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 39,43,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 14 gm/kg/19D (intermittent) Behavioral - tolerance Nutritional and Gross Metabolic - body temperature decrease BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 40,1517,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 16 gm/kg/19D (intermittent) Nutritional and Gross Metabolic - body temperature decrease BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981- Volume(issue)/page/year: 40,1517,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 140 mL/kg/2W (continuous) Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 58,876,2006
TDLo - Lowest published toxic dose Unreported Rodent - mouse 8 gm/kg/4D (intermittent) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
TDLo - Lowest published toxic dose Unreported Rodent - mouse 16 gm/kg/8D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
TDLo - Lowest published toxic dose Unreported Rodent - mouse 16 gm/kg/8D (intermittent) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 32,421,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 980 gm/kg/8W (continuous) Liver - changes in liver weight Kidney/Ureter/Bladder - changes in kidney weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1378,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 72 mL/kg/4W (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1503,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 355.5 gm/kg/45D (intermittent) Liver - other changes Kidney/Ureter/Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1627,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 1814.4 gm/kg/12W (continuous) Vascular - measurement of regional blood flow Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Metabolism (Intermediary) - lipids including transport FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,1940,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 284.4 gm/kg/45D (intermittent) Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - effect on Sodium-Potassium pump SIMEJ* Singapore medical journal(Singapore, Singapore Medical Assn.) V.1- 1960- Volume(issue)/page/year: 47,864,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 355.5 gm/kg/45D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects Biochemical - Metabolism (Intermediary) - lipids including transport SIMEJ* Singapore medical journal(Singapore, Singapore Medical Assn.) V.1- 1960- Volume(issue)/page/year: 48,311,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 13920 mg/kg/3D (intermittent) Behavioral - alteration of classical conditioning NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 30,256,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 15000 mg/kg/3D (intermittent) Brain and Coverings - changes in brain weight NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 30,228,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 21 gm/kg/3W (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 46,2658,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 1344 gm/kg/8W (intermittent) Liver - hepatitis (hepatocellular necrosis), diffuse Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - lipids including transport TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 252,64,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 665 mL/kg/6W (continuous) Vascular - contraction (isolated tissues) Nutritional and Gross Metabolic - weight loss or decreased weight gain BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 153,468,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 665 mL/kg/6W (continuous) Vascular - contraction (isolated tissues) Vascular - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 153,468,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 324000 mg/kg/90D (intermittent) Liver - fatty liver degeneration Liver - other changes Kidney/Ureter/Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 657000 mg/kg/90D (intermittent) Cardiac - changes in heart weight Liver - changes in liver weight Kidney/Ureter/Bladder - changes in kidney weight HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 252000 mg/kg/90D (intermittent) Endocrine - changes in thymus weight HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 2016 gm/kg/36W (intermittent) Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Primate - monkey 13500 gm/kg/72W (intermittent) Liver - fatty liver degeneration HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 35 gm/kg/1W (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 25000 mg/m3/14D (intermittent) Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen Blood - other changes HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - mouse 22000 mg/m3/20D (intermittent) Blood - thrombocytopenia HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Unreported Primate - monkey 261000 mg/kg/90D (intermittent) Endocrine - changes in luteinizing hormone Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in uterine weight HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 25200 mg/kg/7D (intermittent) Related to Chronic Data - death HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Parenteral Rodent - rat 336000 mg/kg/4W (intermittent) Musculoskeletal - osteoporosis Musculoskeletal - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,193,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 540000 mg/kg/45D (intermittent) Liver - other changes Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,237,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 112000 mg/kg/4W (continuous) Endocrine - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,281,2009
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 13.2 gm/kg/6D (intermittent) Brain and Coverings - other degenerative changes NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,459,2009
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 26.4 gm/kg/6D (intermittent) Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,459,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 28000 mg/kg/7D (continuous) Liver - other changes TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,339,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 56000 mg/kg/7D (continuous) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: -,339,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 963.2 gm/kg/16W (continuous) Behavioral - food intake (animal) Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 Volume(issue)/page/year: 22,65,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 25200 mg/kg/7D (intermittent) Behavioral - food intake (animal) Lungs, Thorax, or Respiration - respiratory depression Related to Chronic Data - death HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 522 gm/kg/90D (intermittent) Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Kidney/Ureter/Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 360 gm/kg/90D (intermittent) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 1440 gm/kg/90D (intermittent) Liver - changes in liver weight Kidney/Ureter/Bladder - changes in kidney weight Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 300 gm/kg/12W (continuous) Liver - other changes Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation Biochemical - Metabolism (Intermediary) - other proteins CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 180,31,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 336 gm/kg/12W (continuous) Vascular - BP elevation not characterized in autonomic section Vascular - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 26,427,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 56.25 gm/kg/90D (continuous) Gastrointestinal - gastritis Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 28,591,2008
TDLo - Lowest published toxic dose Oral Rodent - mouse 672000 mg/kg/12W (continuous) Brain and Coverings - other degenerative changes Cardiac - changes in heart weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 187,149,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 175 mL/kg/10W (intermittent) Brain and Coverings - other degenerative changes Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Related to Chronic Data - changes in testicular weight BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004- Volume(issue)/page/year: 101,320,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 16000 mg/kg/8D (intermittent) Behavioral - changes in motor activity (specific assay) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 201,249,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 48000 mg/kg/8D (intermittent) Behavioral - somnolence (general depressed activity) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 201,249,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 22.4 gm/m3/5D (intermittent) Biochemical - Neurotransmitters or modulators (putative) - dopamine at other sites PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 193,495,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 14000 mg/kg/7D (intermittent) Behavioral - changes in motor activity (specific assay) PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 197,361,2008
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 5400 mg/kg/2D (intermittent) Behavioral - tolerance PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 194,139,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 8000 mg/kg/4D (intermittent) Behavioral - changes in motor activity (specific assay) Behavioral - alteration of classical conditioning PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 195,103,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 469 gm/kg/12W (intermittent) Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Metabolism (Intermediary) - other proteins JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 329,952,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 194 gm/kg/6W (continuous) Nutritional and Gross Metabolic - weight loss or decreased weight gain JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 298 gm/kg/8W (continuous) Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 298 gm/kg/8W (continuous) Behavioral - food intake (animal) JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 2070 gm/kg/0.5Y (continuous) Liver - other changes Endocrine - other changes Biochemical - Metabolism (Intermediary) - lipids including transport JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 2070 gm/kg/0.5Y (continuous) Liver - other changes Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 331,23,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 213.15 gm/kg/15D (continuous) Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - withdrawal FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: -,1,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 355.5 gm/kg/45D (intermittent) Liver - hepatitis (hepatocellular necrosis), diffuse Liver - liver function tests impaired Kidney/Ureter/Bladder - renal function tests depressed FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 21,355,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 300 gm/kg/60D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - peptidases Biochemical - Metabolism (Intermediary) - other proteins FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 21,507,2007
TDLo - Lowest published toxic dose Oral Rodent - rat 300 gm/kg/60D (intermittent) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - effect on Sodium-Potassium pump FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 47,1958,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 1512 gm/kg/90D (intermittent) Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Biochemical - Metabolism (Intermediary) - lipids including transport FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 47,2666,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 96 gm/kg/16D (intermittent) Nutritional and Gross Metabolic - weight loss or decreased weight gain NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 31,303,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 42 gm/kg/7D (intermittent) Behavioral - alteration of classical conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,158,2010
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 180 gm/kg/45D (intermittent) Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,164,2010
TDLo - Lowest published toxic dose Oral Rodent - rat 70 gm/kg/10W (intermittent) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation PAINDB Pain. (Elsevier North Holland, Netherlands) V.1- 1975- Volume(issue)/page/year: 145,129,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 355.5 gm/kg/45D (intermittent) Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 21,621,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 40 gm/kg/8D (intermittent) Liver - liver function tests impaired Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 48,1632,2010
TDLo - Lowest published toxic dose Oral Rodent - rat 355.5 gm/kg/9W (intermittent) Liver - other changes Biochemical - Metabolism (Intermediary) - other proteins Biochemical - Metabolism (Intermediary) - effect on mitochondrial function FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947- Volume(issue)/page/year: 81,1239,2010
TDLo - Lowest published toxic dose Unreported Rodent - rat 20 gm/kg/10D (intermittent) Behavioral - alteration of classical conditioning NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,503,2010
TDLo - Lowest published toxic dose Oral Rodent - rat 16 gm/kg/5D (intermittent) Liver - hepatitis (hepatocellular necrosis), zonal Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Metabolism (Intermediary) - lipids including transport CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 47,730,2009

TUMORIGENIC DATA

Type of Test Route of Exposure or Administration Species/Test System Dose Data Toxic Effects Reference
TDLo - Lowest published toxic dose Oral Rodent - mouse 320 mg/kg/50W (intermittent) Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 13,345,1981
TDLo - Lowest published toxic dose Rectal Rodent - mouse 120 gm/kg/18W (intermittent) Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie. (Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see ZIEKBA. Volume(issue)/page/year: 59,203,1928
TD - Toxic dose (other than lowest) Oral Rodent - mouse 400 gm/kg/57W (intermittent) Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie. (Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see ZIEKBA. Volume(issue)/page/year: 59,203,1928

REPRODUCTIVE DATA

Type of Test Route of Exposure or Administration Species/Test System Dose Data Sex/Duration Toxic Effects Reference
TDLo - Lowest published toxic dose Oral Human - woman 41 gm/kg female 41 week(s) after conception Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - drug dependence AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 129,1075,1975
TDLo - Lowest published toxic dose Oral Human - woman 250 mg/kg female 37 week(s) after conception Reproductive - Effects on Embryo or Fetus - other effects to embryo AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 145,251,1983
TDLo - Lowest published toxic dose Intravenous Human - woman 8 gm/kg female 32 week(s) after conception Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 134,419,1980
TDLo - Lowest published toxic dose Intrauterine Human - woman 200 mg/kg female 5 day(s) pre-mating Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 14,280,1969
TDLo - Lowest published toxic dose Oral Rodent - rat 78 gm/kg female 7-19 day(s) after conception Reproductive - Effects on Newborn - biochemical and metabolic PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 59,577,1998
TDLo - Lowest published toxic dose Oral Rodent - rat 4 gm/kg female 13 day(s) after conception Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 15(2),23,1981
TDLo - Lowest published toxic dose Oral Rodent - rat 322 gm/kg male 35 day(s) pre-mating Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 23,176,1978
TDLo - Lowest published toxic dose Oral Rodent - rat 12 gm/kg female 9-12 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) PLPSAX Physiological Psychology. (Austin, TX) V.1-14, 1973-86. Volume(issue)/page/year: 7,311,1979
TDLo - Lowest published toxic dose Oral Rodent - rat 132 gm/kg female 1-22 day(s) after conception Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,217,1981
TDLo - Lowest published toxic dose Oral Rodent - rat 24 gm/kg female 14-16 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - other developmental abnormalities TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,41A,1981
TDLo - Lowest published toxic dose Oral Rodent - rat 354 gm/kg lactating female 10 day(s) post-birth Reproductive - Effects on Newborn - biochemical and metabolic RCPBDC Research Communications in Psychology, Psychiatry and Behavior. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1976- Volume(issue)/page/year: 2,119,1977
TDLo - Lowest published toxic dose Oral Rodent - rat 4 gm/kg female 6-15 day(s) after conception Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - urogenital system JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 10,267,1982
TDLo - Lowest published toxic dose Oral Rodent - rat 35295 mg/kg female 1-15 day(s) after conception Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970- Volume(issue)/page/year: 22(1),71,1991
TDLo - Lowest published toxic dose Oral Rodent - rat 44 gm/kg female 7-17 day(s) after conception Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),10,1985
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 20000 ppm/7H female 1-22 day(s) after conception Reproductive - Specific Developmental Abnormalities - other developmental abnormalities TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29(2),48A,1984
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 15 gm/kg female 8-13 day(s) after conception Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 36,31A,1987
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 2240 mg/kg female 9-12 day(s) after conception Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969- Volume(issue)/page/year: 38,5835,1978
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 600 mg/kg female 8-15 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),12A,1982
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 600 mg/kg female 8-15 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 21,108,1983
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 600 mg/kg female 8-15 day(s) after conception Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 21,108,1983
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 3600 mg/kg female 7-8 day(s) after conception Reproductive - Effects on Newborn - behavioral NELED5 Neuroscience Letters. (Elsevier Scientific Publishers Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 289,13,2000
TDLo - Lowest published toxic dose Intravenous Rodent - rat 4 gm/kg female 6-7 day(s) after conception Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - musculoskeletal system RECYAR Revue Roumaine d'Embryologie et de Cytologia, Serie d'Embrologie. (Bucharest, Romania) V.1-8, 1964-71. Volume(issue)/page/year: 8,105,1971
TDLo - Lowest published toxic dose Intravenous Rodent - rat 3 gm/kg female 6-7 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) RECYAR Revue Roumaine d'Embryologie et de Cytologia, Serie d'Embrologie. (Bucharest, Romania) V.1-8, 1964-71. Volume(issue)/page/year: 8,105,1971
TDLo - Lowest published toxic dose Intravenous Rodent - rat 4 gm/kg female 6-7 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities RECYAR Revue Roumaine d'Embryologie et de Cytologia, Serie d'Embrologie. (Bucharest, Romania) V.1-8, 1964-71. Volume(issue)/page/year: 8,105,1971
TDLo - Lowest published toxic dose Intracerebral Rodent - rat 5 mg/kg female 1 day(s) pre-mating Reproductive - Fertility - other measures of fertility JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 42,199,1975
TDLo - Lowest published toxic dose Unreported Rodent - rat 60 gm/kg female 9-14 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45(1),83,1982
TDLo - Lowest published toxic dose Intratesticular Rodent - rat 400 mg/kg male 1 day(s) pre-mating Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,884,1973
TDLo - Lowest published toxic dose Intrauterine Rodent - rat 2400 mg/kg female 10 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 14,316,1976
TDLo - Lowest published toxic dose Multiple routes Rodent - rat 642 gm/kg female 1-21 day(s) after conception lactating female 23 day(s) post-birth Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year: 10,435,1977
TDLo - Lowest published toxic dose Multiple routes Rodent - rat 373 gm/kg lactating female 23 day(s) post-birth Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical DEPBA5 Developmental Psychobiology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1968- Volume(issue)/page/year: 10,435,1977
TDLo - Lowest published toxic dose Oral Rodent - mouse 162 gm/kg female 11-19 day(s) after conception Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,56A,1983
TDLo - Lowest published toxic dose Oral Rodent - mouse 21 gm/kg female 1-21 day(s) after conception Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral JSALDP Journal of Studies on Alcohol. (P.O. Box 969, Piscataway, NJ 08854) V.36- 1975- Volume(issue)/page/year: 38,1696,1977
TDLo - Lowest published toxic dose Oral Rodent - mouse 5800 mg/kg female 7 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
TDLo - Lowest published toxic dose Oral Rodent - mouse 75600 mg/kg female 5-11 day(s) after conception Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 23,127,1979
TDLo - Lowest published toxic dose Oral Rodent - mouse 5500 mg/kg female 9 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 24(1),53A,1981
TDLo - Lowest published toxic dose Oral Rodent - mouse 1680 gm/kg male 70 day(s) pre-mating Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 39,542,1980
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 5800 mg/kg female 10 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 5800 mg/kg female 7 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 5622 ug/kg female 10 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 124,676,1976
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4 mg/kg female 10 day(s) after conception Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 193,515,1979
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 4300 mg/kg female 10 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY. Volume(issue)/page/year: 2,227,1980
TDLo - Lowest published toxic dose Oral Mammal - dog 21600 mg/kg female 1-60 day(s) after conception Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 36,285,1977
TDLo - Lowest published toxic dose Oral Mammal - dog 260 gm/kg female 1-62 day(s) after conception Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 4,123,1980
TDLo - Lowest published toxic dose Oral Mammal - dog 221 gm/kg female 1-47 day(s) after conception Reproductive - Fertility - abortion ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 4,123,1980
TDLo - Lowest published toxic dose Intratesticular Mammal - dog 100 mg/kg male 1 day(s) pre-mating Reproductive - Paternal Effects - testes, epididymis, sperm duct FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 24,884,1973
TDLo - Lowest published toxic dose Oral Primate - monkey 78 gm/kg female 4-23 week(s) after conception Reproductive - Fertility - abortion TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,345,1987
TDLo - Lowest published toxic dose Oral Primate - monkey 400 mg/kg female 2-21 week(s) after conception Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29,49,1984
TDLo - Lowest published toxic dose Oral Primate - monkey 206 gm/kg female 90 day(s) pre-mating Reproductive - Maternal Effects - menstrual cycle changes or disorders SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 221,677,1983
TDLo - Lowest published toxic dose Oral Primate - monkey 32400 mg/kg female 2-19 week(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,29,1991
TDLo - Lowest published toxic dose Oral Primate - monkey 43200 mg/kg female 1-24 week(s) after conception Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,29,1991
TDLo - Lowest published toxic dose Oral Rodent - rabbit 3945 mg/kg female 1 day(s) pre-mating Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 34,275,1966
TDLo - Lowest published toxic dose Oral Rodent - rabbit 3750 mg/kg female 1 day(s) pre-mating Reproductive - Fertility - other measures of fertility IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 58,501,1970
TDLo - Lowest published toxic dose Intravenous Rodent - rabbit 15 mg/kg female 15-29 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo JPDSA3 Journal of Pediatric Surgery. (Grune and Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1966- Volume(issue)/page/year: 29,1030,1994
TDLo - Lowest published toxic dose Oral Mammal - pig 2648 gm/kg female 78 week(s) pre-mating 1-16 week(s) after conception Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 5,229,1983
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 90 gm/kg female 1-68 day(s) after conception Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 127,438,1957
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 240 gm/kg female 2-61 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System DBRRDB Developmental Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1981- Volume(issue)/page/year: 106,39,1998
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 264 gm/kg female 2-67 day(s) after conception Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical ACRSDM Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1977- Volume(issue)/page/year: 23,1816,1999
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 72 gm/kg female 45-62 day(s) after conception Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) FAJOEC FASEB Journal. Official Publication of the Federation of American Societies for Experimental Biology. (Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1987- Volume(issue)/page/year: 14,A1447,2000
TDLo - Lowest published toxic dose Intravenous Mammal - domestic 94 gm/kg female 14-21 week(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 12,329,1980
TDLo - Lowest published toxic dose Intravenous Mammal - domestic 40 gm/kg female 14-17 week(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - biochemical and metabolic NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 3,105,1981
TDLo - Lowest published toxic dose Intravenous Mammal - domestic 1 gm/kg female 18 week(s) after conception Reproductive - Specific Developmental Abnormalities - respiratory system AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 151,859,1985
TDLo - Lowest published toxic dose Oral Mammal - species unspecified 31500 mg/kg female 15-35 day(s) after conception Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 30,203,1984
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 76000 mg/kg female 43-62 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Embryo or Fetus - other effects to embryo NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 23,355,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 191220 mg/kg female 2-20 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 23,453,2001
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 264000 mg/kg female 2-67 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - physical NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 22,183,2000
TDLo - Lowest published toxic dose Intravenous Mammal - domestic 29000 mg/kg female 106-134 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - behavioral NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 22,205,2000
TDLo - Lowest published toxic dose Oral Rodent - rat 30 gm/kg female 1-20 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - other neonatal measures or effects TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 163,15,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 20 gm/kg multigenerations Reproductive - Specific Developmental Abnormalities - hepatobiliary system Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
TDLo - Lowest published toxic dose Oral Rodent - mouse 20 gm/kg multigenerations Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
TDLo - Lowest published toxic dose Oral Rodent - mouse 20 gm/kg multigenerations Reproductive - Specific Developmental Abnormalities - urogenital system NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
TDLo - Lowest published toxic dose Oral Rodent - rat 22.5 gm/kg female 11-20 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - other postnatal measures or effects NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 24,719,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 40 gm/kg female 1-20 day(s) after conception Reproductive - Specific Developmental Abnormalities - other developmental abnormalities Reproductive - Specific Developmental Abnormalities - Central Nervous System FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45,68,1982
TDLo - Lowest published toxic dose Oral Rodent - rat 42 gm/kg female 1-21 day(s) after conception Reproductive - Specific Developmental Abnormalities - other developmental abnormalities FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 45,66,1982
TDLo - Lowest published toxic dose Oral Rodent - mouse 700 gm/kg male 7 day(s) pre-mating female 7 day(s) pre-mating 21 day(s) after conception Reproductive - Effects on Newborn - live birth index (measured after birth) NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: #PB85118651
TDLo - Lowest published toxic dose Oral Rodent - rat 240 gm/kg male 30 day(s) pre-mating Reproductive - Specific Developmental Abnormalities - urogenital system FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 47,82,1984
TDLo - Lowest published toxic dose Oral Rodent - rat 65 gm/kg female 7-19 day(s) after conception Reproductive - Specific Developmental Abnormalities - endocrine system ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 138,389,1997
TDLo - Lowest published toxic dose Oral Rodent - rat 75 gm/kg female 7-21 day(s) after conception Reproductive - Specific Developmental Abnormalities - endocrine system ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 138,389,1997
TDLo - Lowest published toxic dose Oral Rodent - rat 112 mg/kg male 14 day(s) pre-mating Reproductive - Effects on Newborn - biochemical and metabolic FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48,86,1985
TDLo - Lowest published toxic dose Oral Rodent - rat 147 mg/kg female 1-21 day(s) after conception Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - delayed effects FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 47,84,1984
TDLo - Lowest published toxic dose Oral Rodent - rat 60000 mg/kg lactating female 1-30 day(s) post-birth Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - delayed effects FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48,93,1985
TDLo - Lowest published toxic dose Oral Rodent - rat 900 mL/kg female 19 day(s) pre-mating - 21 day(s) post-birth Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 24,275,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 110 gm/kg female 1-23 day(s) after conception Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
TDLo - Lowest published toxic dose Oral Rodent - rat 135 gm/kg female 1 day(s) after conception - 7 day(s) post-birth Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 59,44,1996
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2.9 gm/kg female 8 day(s) after conception Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72,171,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 210 gm/kg female 6-20 day(s) after conception Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 72(Suppl 1),341,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 11.25 mg/kg female 7-9 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,475,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 15 mg/kg female 6-8 day(s) after conception Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 17,475,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 90 mg/kg male 30 day(s) pre-mating Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 71,3059,2002
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 264 gm/kg female 2-67 day(s) after conception Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - other postnatal measures or effects NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 25,59,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 30 gm/kg female 16-20 day(s) after conception Reproductive - Effects on Newborn - other postnatal measures or effects NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 25,447,2003
TDLo - Lowest published toxic dose Oral Rodent - rat 120 gm/kg female 1-20 day(s) after conception Reproductive - Effects on Newborn - other postnatal measures or effects NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 25,447,2003
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 272 gm/kg female 2-67 day(s) after conception Reproductive - Effects on Newborn - other postnatal measures or effects Reproductive - Effects on Newborn - delayed effects NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,59,2004
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 57 gm/kg female 43-62 day(s) after conception Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 26,543,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 45 gm/kg female 15-22 day(s) after conception lactating female 7 day(s) post-birth Reproductive - Effects on Newborn - behavioral NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 24,691,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 45 gm/kg female 15-22 day(s) after conception lactating female 7 day(s) post-birth Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987- Volume(issue)/page/year: 26,191,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 10400 mg/kg female 7-19 day(s) after conception Reproductive - Tumorigenic effects - transplacental tumorigenesis Reproductive - Effects on Newborn - delayed effects BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 90,2225,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 110 gm/kg female 10-20 day(s) after conception Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - biochemical and metabolic NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,73,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 120 gm/kg female 6-15 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 44,57,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 16.25 gm/kg female 7-19 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Tumorigenic effects - other reproductive system tumors Reproductive - Effects on Newborn - biochemical and metabolic BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 90,2225,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 54 gm/kg female 6-14 day(s) after conception Reproductive - Maternal Effects - other effects TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 78,280,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 22.8 gm/kg female 6-8 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 20,453,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 22.8 gm/kg female 6-8 day(s) after conception Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - eye/ear REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 20,453,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 60 gm/kg female 6-15 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 577S,1,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 36.5 gm/kg female 30 day(s) pre-mating - 21 day(s) post-birth Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - behavioral NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,585,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 292 gm/kg female 30 day(s) pre-mating - 21 day(s) post-birth Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 27,585,2005
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 204 gm/kg female 0-67 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 308,650,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 50 gm/kg female 6-15 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,61,2006
TDLo - Lowest published toxic dose Oral Rodent - mouse 50 gm/kg female 6-15 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,61,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 22.8 gm/kg female 6-8 day(s) after conception Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,263,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 94500 mg/kg female 1-21 day(s) after conception Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Oral Rodent - rat 94500 mg/kg female 1-21 day(s) after conception Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - other postnatal measures or effects TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (5),13,2002
TDLo - Lowest published toxic dose Oral Human - woman 5860 mL/kg female 3 year(s) pre-mating - 100 day(s) post-birth Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - delayed effects INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 37,129,2005
TDLo - Lowest published toxic dose Oral Rodent - rat 99000 mg/kg multigenerations Reproductive - Effects on Newborn - biochemical and metabolic NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 28,238,2006
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 264 gm/kg female 2-67 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 28,333,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 1188 gm/kg male 55 day(s) pre-mating Reproductive - Paternal Effects - impotence Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,599,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 1188 gm/kg male 55 day(s) pre-mating Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,599,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 5.8 gm/kg female 3-5 day(s) after conception Reproductive - Specific Developmental Abnormalities - musculoskeletal system BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 70,163,2004
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 22.8 gm/kg female 6-8 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998- Volume(issue)/page/year: 67,2073,2004
TDLo - Lowest published toxic dose Oral Rodent - rat 21 gm/kg female 8-14 day(s) after conception Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects Reproductive - Effects on Newborn - delayed effects ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 6,353,1989
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 260 gm/kg female 2-67 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 41,577,2007
TDLo - Lowest published toxic dose Oral Rodent - mouse 360 gm/kg male 60 day(s) pre-mating female 60 day(s) pre-mating Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) BDERB* Birth defects research. Part B, Developmental and reproductive toxicology (Hoboken, N.J. : Wiley-Liss) V.68- 2003- Volume(issue)/page/year: 71,135,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 180 gm/kg female 60 day(s) pre-mating Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) BDERB* Birth defects research. Part B, Developmental and reproductive toxicology (Hoboken, N.J. : Wiley-Liss) V.68- 2003- Volume(issue)/page/year: 71,135,2004
TDLo - Lowest published toxic dose Oral Rodent - mouse 3270 gm/kg female 13 week(s) pre-mating - 3 week(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 73,980,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 18000 mg/kg female 5-21 day(s) after conception Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 73,897,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 3210 gm/kg female 13 week(s) pre-mating - 16 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 73,65,2005
TDLo - Lowest published toxic dose Oral Rodent - mouse 2900 mg/kg female 8 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TERMG* Teratology Society. Platform Sessions Abstracts. Concurrent Platform Session III. Mechanism Genomics RA Volume(issue)/page/year: -,234,2003
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2900 mg/kg female 8 day(s) after conception Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TERP2* Teratology Society. Poster Session Abstracts. Joint TS/NBTS Poster Session II Volume(issue)/page/year: -,368,2005
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2900 mg/kg female 8 day(s) after conception Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TERST* Teratology Society. Platform Sessions Abstracts. Student Plenary Session Volume(issue)/page/year: -,315,2006
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 2900 mg/kg female 8 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TERST* Teratology Society. Platform Sessions Abstracts. Student Plenary Session Volume(issue)/page/year: -,315,2006
TDLo - Lowest published toxic dose Oral Rodent - rat 378 gm/kg male 9 week(s) pre-mating Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 252 gm/kg female 12 day(s) after conception - 10 day(s) post-birth Reproductive - Effects on Newborn - other neonatal measures or effects Reproductive - Effects on Newborn - delayed effects HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 20000 ppm female 1-19 day(s) after conception Reproductive - Maternal Effects - other effects HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 43 gm/kg female 1 day(s) after conception - 21 day(s) post-birth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 175000 mg/kg female 28 day(s) pre-mating - 22 day(s) after conception Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 182250 mg/kg female 6-20 day(s) after conception Reproductive - Effects on Newborn - behavioral HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
TDLo - Lowest published toxic dose Oral Rodent - rat 273 gm/kg female 21 day(s) after conception - 21 day(s) post-birth Reproductive - Effects on Newborn - behavioral NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,23,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 2398 mL/kg female 60 day(s) pre-mating 3 week(s) after conception lactating female 4 week(s) post-birth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 30,59,2009
TDLo - Lowest published toxic dose Oral Rodent - mouse 150 gm/kg female 4-9 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TCLo - Lowest published toxic concentration Inhalation Rodent - rat 20000 ppm female 1-19 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 868 gm/kg male 28 day(s) pre-mating Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 25200 mg/kg female 8-14 day(s) after conception Reproductive - Maternal Effects - other effects HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 35000 mg/kg female 8-14 day(s) after conception Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - live birth index (measured after birth) HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 2173.5 gm/kg multigenerations Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - live birth index (measured after birth) HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - mouse 1053.5 gm/kg male 49 day(s) pre-mating Reproductive - Paternal Effects - other effects on male HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Oral Rodent - rat 784 gm/kg female 56 day(s) pre-mating Reproductive - Maternal Effects - other effects HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 30 mg/kg female 7 day(s) after conception Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 79,513,2007
TDLo - Lowest published toxic dose Intraperitoneal Rodent - rat 18 gm/kg female 5-22 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003- Volume(issue)/page/year: 85,791,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 96 gm/kg female 5-20 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 31,303,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 96 gm/kg female 5-20 day(s) after conception Reproductive - Effects on Newborn - physical NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 31,303,2009
TDLo - Lowest published toxic dose Oral Rodent - guinea pig 260 gm/kg female 1-65 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - hepatobiliary system NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,164,2010
TDLo - Lowest published toxic dose Oral Rodent - rat 126 gm/kg lactating female 21 day(s) post-birth Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - other postnatal measures or effects Reproductive - Effects on Newborn - delayed effects FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 23(Suppl 1),16,2009
TDLo - Lowest published toxic dose Oral Rodent - rat 1680 gm/kg female 8 week(s) pre-mating - 7 day(s) post-birth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 48,3486,2010
TDLo - Lowest published toxic dose Oral Rodent - rat 1960 gm/kg female 8 week(s) pre-mating - 21 day(s) post-birth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 48,3486,2010
TDLo - Lowest published toxic dose Intraperitoneal Rodent - mouse 5.8 gm/kg female 7 day(s) after conception Reproductive - Specific Developmental Abnormalities - Central Nervous System NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 33,231,2011

MUTATION DATA

Type of Test Route of Exposure or Administration Species/Test System Dose Data Reference
Mutation in microorganisms   Bacteria - Salmonella typhimurium 11 pph ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 52,225,1990
Mutation in microorganisms   Bacteria - Escherichia coli 140 gm/L MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,97,1984
DNA repair   Bacteria - Escherichia coli 5 mg/well MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984
Sex chromosome loss and nondisjunction Oral Insect - Drosophila melanogaster 10 pph MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,95,1992
Mutation in microorganisms   Yeast - Saccharomyces cerevisiae 24 pph GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965- Volume(issue)/page/year: 15,927,1979
DNA damage   Yeast - Saccharomyces cerevisiae 850 mmol/L MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 326,165,1995
Mutation in microorganisms   Mold - Aspergillus nidulans 20 pph MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,51,1977
Gene conversion and mitotic recombination   Mold - Aspergillus nidulans 5 pph MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,51,1977
Sex chromosome loss and nondisjunction   Mold - Aspergillus nidulans 30 gm/L EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 31,81,1979
Cytogenetic analysis Parenteral Insect - grasshopper 500 mmol/L NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 51,646,1964
DNA inhibition   Human Lymphocyte 220 mmol/L PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982
Cytogenetic analysis   Human Lymphocyte 1160 gm/L AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 85A,25,1977
Cytogenetic analysis   Human Fibroblast 12000 ppm ACYTAN Acta Cytologica. (Science Printers and Pub., Inc., 2 Jacklynn Ct., St. Louis, MO 63132) V.1- 1957- Volume(issue)/page/year: 16,41,1972
Cytogenetic analysis   Human Leukocyte 1 pph/72H (continuous) TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959- Volume(issue)/page/year: 20,421,1978
Sister chromatid exchange   Human Lymphocyte 500 ppm/72H (continuous) CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973- Volume(issue)/page/year: 27,66,1980
DNA damage Oral Rodent - rat 4 gm/kg MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 345,191,1995
Mutation test systems - not otherwise specified Intraperitoneal Rodent - rat 250 gm/kg/16D (continuous) CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 56,195,1988
Mutation test systems - not otherwise specified Oral Rodent - rat 3 gm/kg APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,125,1981
Cytogenetic analysis Oral Rodent - rat 2 gm/kg TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 14(5),48,1980
Micronucleus test Intraperitoneal Rodent - mouse 1240 mg/kg/2D AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 85A,25,1977
Cytogenetic analysis Oral Rodent - mouse 40 gm/kg NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 302,258,1983
Sister chromatid exchange Oral Rodent - mouse 420 mg/kg/3W MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,291,1979
Sex chromosome loss and nondisjunction Oral Rodent - mouse 5 gm/kg CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973- Volume(issue)/page/year: 44,7,1987
Dominant lethal test Oral Rodent - mouse 3720 mg/kg/3D AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 85A,25,1977
Sperm Morphology Oral Rodent - mouse 1500 mg/kg/50D MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 65,229,1979
Cytogenetic analysis   Rodent - hamster Ovary 100 ppm ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 6),72,1986
Cytogenetic analysis   Rodent - hamster Embryo 1 pph MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,207,1988
Cytogenetic analysis   Rodent - hamster Ovary 160 mmol/L BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year: 106,169,1987
Sister chromatid exchange   Rodent - hamster Ovary 3900 mg/L MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,85,1983
Micronucleus test   Mammal - dog Lymphocyte 400 umol/L NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A075-605
DNA adduct Oral Rodent - rat 5 gm/kg MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 479,81,2001
DNA adduct Oral Rodent - rat 3 gm/kg/7D MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 479,81,2001
Cytogenetic analysis   Human Lymphocyte 2.5 pph/24H MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 537,117,2003
Micronucleus test Intramuscular Fish - not otherwise specified 1 pph MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 542,1,2003
Cytogenetic analysis Intramuscular Fish - not otherwise specified 1 pph MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 542,1,2003
Cytogenetic analysis Oral Human 49014 gm/kg/25Y MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 560,187,2004
Micronucleus test   Human Liver 15 mmol/L/24H TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 198,315,2004
DNA damage   Bacteria - Salmonella typhimurium 15 pph/120M MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 575,34,2005
DNA repair   Bacteria - Salmonella typhimurium 15 pph/120M MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 575,34,2005
Specific locus test Oral Rodent - rat 56 gm/kg/4W MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 577S,1,2005
Micronucleus test Oral Human 817.6 gm/kg/6Y (intermittent) MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 615,134,2007
DNA damage Oral Rodent - rat 3150 gm/kg/1Y (intermittent) TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 254,11,2008
Cytogenetic analysis Oral Rodent - rat 504 gm/kg/6W (intermittent) HPV112 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Aluminum Alkoxides Category.pdf http://www.epa.gov/HPV/pubs/summaries/almalkct/c16706tc.htm Volume(issue)/page/year: -,-,2008
Micronucleus test   Human Cells - not otherwise specified 4 gm/L MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 17,509,2002
Sister chromatid exchange   Rodent - hamster Ovary 31.6 gm/L/1H HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
Sister chromatid exchange   Human Lymphocyte 0.5 gm/L/72H HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
Sister chromatid exchange   Human Lymphocyte 10 gm/L/24H HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
Sister chromatid exchange Intraperitoneal Rodent - mouse 0.6 mg/kg HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
Sister chromatid exchange Oral Rodent - mouse 2800 gm/kg/10W (intermittent) HPV228 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Ethanol.pdf http://www.epa.gov/HPV/pubs/summaries/ethanol/c12981tc.htm Volume(issue)/page/year: -,-,2001
Gene conversion and mitotic recombination   Insect - Drosophila melanogaster Cells - not otherwise specified 8.4 pph EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 48,644,2007
DNA damage   Human Lymphocyte 100 mmol/L/3H MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 721,171,2011

REVIEWS

ACGIH TLV-STEL 1000 ppm DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,2010
ACGIH TLV-Confirmed animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,2010
IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 44,35,1988
TOXICOLOGY REVIEW IRXPAT International Review of Experimental Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 11,177,1972
TOXICOLOGY REVIEW AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 56,291,1975
TOXICOLOGY REVIEW AICMA2 Archivos del Instituto de Cardiologia de Mexico. (Instituto de Cardiologia de Mexico, Juan Badiano No.1, 14080 Mexico City, Mexico) V.14- 1944- Volume(issue)/page/year: 44,874,1974
TOXICOLOGY REVIEW MAEPBU Methods and Achievements in Experimental Pathology. (S. Karger AG, Postfach, CH-4009, Basel, Switzerland) V.1- 1966- Volume(issue)/page/year: 6,81,1972
TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,433,1970
TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 4,1,1952
TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973
TOXICOLOGY REVIEW SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 209,353,1980
TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 235,1458,1976
TOXICOLOGY REVIEW NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 342,186,2000
TOXICOLOGY REVIEW JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956- Volume(issue)/page/year: 45,7,2000
TOXICOLOGY REVIEW JKMSEH Journal of Korean Medical Science. (Korean Academy of Medical Science, C.P.O. Box 2062, Seoul, S. Korea) V.1- 1986- Volume(issue)/page/year: 17,236,2002
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 23,519,2002
TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 33,407,2003
TOXICOLOGY REVIEW TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 140-141,155,2003
TOXICOLOGY REVIEW TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 140-141,161,2003
TOXICOLOGY REVIEW PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 172,352,2004
TOXICOLOGY REVIEW PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 55,501,1996
TOXICOLOGY REVIEW TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,157,1980
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 24,55,2003
TOXICOLOGY REVIEW REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 22,196,2006
TOXICOLOGY REVIEW TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 16,53,1977
TOXICOLOGY REVIEW TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 127,197,2002
TOXICOLOGY REVIEW TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 134,3,2002
TOXICOLOGY REVIEW PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 174,539,2004
TOXICOLOGY REVIEW ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year: 44,27,2004
TOXICOLOGY REVIEW ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year: 44,87,2004
TOXICOLOGY REVIEW REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 19,421,2005
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 24,41,2003
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 24,266,2003
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 24,151,2003
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 24,456,2003
TOXICOLOGY REVIEW EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 45,271,2005
TOXICOLOGY REVIEW JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 23,289,2003
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 613,17,2006
TOXICOLOGY REVIEW NETOX* NeuroToxicology (Amsterdam : Elsevier Science) V.1- 1979- Volume(issue)/page/year: 26,521,2005
TOXICOLOGY REVIEW EJCCER Oral Oncology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 28B, No. 1- July 1992 Volume(issue)/page/year: 41,956,2005
TOXICOLOGY REVIEW JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 312,875,2005
TOXICOLOGY REVIEW MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 19,251,2004
TOXICOLOGY REVIEW EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 526,113,2005
TOXICOLOGY REVIEW EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 526,163,2005
TOXICOLOGY REVIEW JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987- Volume(issue)/page/year: 20,143,2006
TOXICOLOGY REVIEW AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000- Volume(issue)/page/year: 7,63,2006
TOXICOLOGY REVIEW BIPHEX Biomedicine & Pharmacotherapy (Editions Scientifiques et Medicales Elsevier, Journals Fulfilment Department, 23 rue Linois, F -75724 Paris Cedex 15, France OR Editions Scientifiques et Medicales Elsevier, P.O.BOX 7247-7576, Philadelphia, PA 19170-7576,USA) V. 36- Jan.1982-) Volume(issue)/page/year: 58,84,2004
TOXICOLOGY REVIEW CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994- Volume(issue)/page/year: 9,6,2002
TOXICOLOGY REVIEW ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 Volume(issue)/page/year: -,62,2005
TOXICOLOGY REVIEW DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978- Volume(issue)/page/year: 39,678,1993
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 628,67,2007
TOXICOLOGY REVIEW JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 318,1,2006
TOXICOLOGY REVIEW ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 Volume(issue)/page/year: -,742,2005
TOXICOLOGY REVIEW ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 Volume(issue)/page/year: -,263,2005
TOXICOLOGY REVIEW ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 Volume(issue)/page/year: -,387,2005
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 584,1,2005
TOXICOLOGY REVIEW NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 29,425,2007
TOXICOLOGY REVIEW ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 41,399,2007
TOXICOLOGY REVIEW ALCOH* Alcohol (Fayetteville, N.Y., New York Ny : Elsevier Science) V.1- 1984- Volume(issue)/page/year: 41,479,2007
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 654,114,2008
TOXICOLOGY REVIEW PHREP* Pharmacological reports : PR (Krakow, Poland : Institute of Pharmacology, Polish Academy of Sciences) V.57- 2005- Volume(issue)/page/year: 57,23,2005
TOXICOLOGY REVIEW PSBUL* Psychopharmacology Bulletin (New York, NY : MedWorks Media) V.3- 1966- Volume(issue)/page/year: 35,89,2001
TOXICOLOGY REVIEW PSBUL* Psychopharmacology Bulletin (New York, NY : MedWorks Media) V.3- 1966- Volume(issue)/page/year: 35,66,2001
TOXICOLOGY REVIEW PSBUL* Psychopharmacology Bulletin (New York, NY : MedWorks Media) V.3- 1966- Volume(issue)/page/year: 37,64,2003
TOXICOLOGY REVIEW JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 Volume(issue)/page/year: 19,111,2006
TOXICOLOGY REVIEW REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 23,125,2007
TOXICOLOGY REVIEW ITODC* Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical Approach. Volume I: Principles and Methods of Immunotoxicology. Edited by: J. Descotes, Elsevier B.V., 2009 Volume(issue)/page/year: -,327,2004
TOXICOLOGY REVIEW HUTOX* Human Toxicology, Edited by: Jacques Descotes, Elsevier B.V., 1996 Volume(issue)/page/year: -,493,1996
TOXICOLOGY REVIEW HUTOX* Human Toxicology, Edited by: Jacques Descotes, Elsevier B.V., 1996 Volume(issue)/page/year: -,577,1996
TOXICOLOGY REVIEW HUTOX* Human Toxicology, Edited by: Jacques Descotes, Elsevier B.V., 1996 Volume(issue)/page/year: -,623,1996
TOXICOLOGY REVIEW TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979- Volume(issue)/page/year: 29,109,2008
TOXICOLOGY REVIEW PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher information, see PHTHDT. Volume(issue)/page/year: 113,229,2007
TOXICOLOGY REVIEW PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher information, see PHTHDT. Volume(issue)/page/year: 116,306,2007
TOXICOLOGY REVIEW AGVBE* Aggression and Violent Behavior (New York : Elsevier) V.1- 1996- Volume(issue)/page/year: 8,155,2003
TOXICOLOGY REVIEW BPRCR* Best Practice & Research. Clinical rheumatology (Amsterdam : Elsevier) V.15- 2001- Volume(issue)/page/year: 17,877,2003
TOXICOLOGY REVIEW AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 53,439,2009
TOXICOLOGY REVIEW BLREV* Blood Reviews (London : Elsevier) V.1- 1987- Volume(issue)/page/year: 3,71,1989
TOXICOLOGY REVIEW BLREV* Blood Reviews (London : Elsevier) V.1- 1987- Volume(issue)/page/year: 4,226,1990
TOXICOLOGY REVIEW COCPH* Clinical Ocular Pharmacology (Fifth Edition), Bartlett, J.D. ed., Elsevier Inc, 2008 Volume(issue)/page/year: -,701,2008
TOXICOLOGY REVIEW COCPH* Clinical Ocular Pharmacology (Fifth Edition), Bartlett, J.D. ed., Elsevier Inc, 2008 Volume(issue)/page/year: -,701,2008
TOXICOLOGY REVIEW HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 26,251,2007
TOXICOLOGY REVIEW DERCL* Dermatologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 27,289,2009
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 682,94,2009
TOXICOLOGY REVIEW ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 83,519,2009
TOXICOLOGY REVIEW MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 22,91,2007
TOXICOLOGY REVIEW PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994- Volume(issue)/page/year: 16,638,2009
TOXICOLOGY REVIEW NEUCL* Neurologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 15,711,1997
TOXICOLOGY REVIEW NCLNA* Neurologic clinics (Elsevier) V.20- 2002 Volume(issue)/page/year: 16,503,1998
TOXICOLOGY REVIEW NEUCL* Neurologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 18,215,2000
TOXICOLOGY REVIEW NEUCL* Neurologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 18,695,2000
TOXICOLOGY REVIEW NCLNA* Neurologic clinics (Elsevier) V.20- 2002 Volume(issue)/page/year: 16,107,1998
TOXICOLOGY REVIEW NEUCL* Neurologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 23,321,2005
TOXICOLOGY REVIEW NEUCL* Neurologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 23,377,2005
TOXICOLOGY REVIEW NEUCL* Neurologic clinics (Philadelphia : Saunders) V.1- 1983- Volume(issue)/page/year: 23,397,2005
TOXICOLOGY REVIEW NBREV* Neuroscience and biobehavioral reviews (New York Ny : Pergamon Press) V.2- 1978- Volume(issue)/page/year: 5,1,1981
TOXICOLOGY REVIEW OSMPR* Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (St. Louis, MO : Mosby-Year Book, Inc.) V.79- 1995- Volume(issue)/page/year: 103,e20,2007
TOXICOLOGY REVIEW NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987- Volume(issue)/page/year: 32,4,2010
TOXICOLOGY REVIEW NTAPM* Neurotoxicology: Approaches And Methods. Louis W. Chang, William Slikker Jr. ed, Academic Press, 1995 Volume(issue)/page/year: -,265,1995
TOXICOLOGY REVIEW NTAPM* Neurotoxicology: Approaches And Methods. Louis W. Chang, William Slikker Jr. ed, Academic Press, 1995 Volume(issue)/page/year: -,617,1995
TOXICOLOGY REVIEW NTAPM* Neurotoxicology: Approaches And Methods. Louis W. Chang, William Slikker Jr. ed, Academic Press, 1995 Volume(issue)/page/year: -,641,1995
TOXICOLOGY REVIEW NTAPM* Neurotoxicology: Approaches And Methods. Louis W. Chang, William Slikker Jr. ed, Academic Press, 1995 Volume(issue)/page/year: -,711,1995
TOXICOLOGY REVIEW NTAPM* Neurotoxicology: Approaches And Methods. Louis W. Chang, William Slikker Jr. ed, Academic Press, 1995 Volume(issue)/page/year: -,727,1995
TOXICOLOGY REVIEW NTAPM* Neurotoxicology: Approaches And Methods. Louis W. Chang, William Slikker Jr. ed, Academic Press, 1995 Volume(issue)/page/year: -,753,1995
TOXICOLOGY REVIEW FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 22(Suppl 1),82,2008
TOXICOLOGY REVIEW TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: -,6,2010
TOXICOLOGY REVIEW NBREV* Neuroscience and biobehavioral reviews (New York Ny : Pergamon Press) V.2- 1978- Volume(issue)/page/year: 11,107,1987
TOXICOLOGY REVIEW MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 26,231,2011
TOXICOLOGY REVIEW REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 31,319,2011
TOXICOLOGY REVIEW FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001- Volume(issue)/page/year: 23(Suppl 1),51,2009
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 727,55,2011
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 723,77,2011
TOXICOLOGY REVIEW REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 32,235,2011
TOXICOLOGY REVIEW NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 31,562,2010
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 728,88,2011
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 728,118,2011
TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 717,67,2011

U.S. STANDARDS AND REGULATIONS

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

EPA FIFRA 1998 STATUS OF PESTICIDES: RED Completed
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 Volume(issue)/page/year: -,290,1998

MSHA STANDARD-air:TWA 1000 ppm (1900 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,103,1971

OSHA PEL (Gen Indu):8H TWA 1000 ppm (1900 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994

OSHA PEL (Construc):8H TWA 1000 ppm (1900 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994

OSHA PEL (Shipyard):8H TWA 1000 ppm (1900 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993

OSHA PEL (Fed Cont):8H TWA 1000 ppm (1900 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994


OCCUPATIONAL EXPOSURE LIMITS

OEL-AUSTRALIA: TWA 1000 ppm (1880 mg/m3), JUL2008

OEL-AUSTRIA: MAK-TMW 1000 ppm (1900 mg/m3);KZW 2000 ppm (3800 mg/m3), 2007

OEL-BELGIUM: TWA 1000 ppm (1907 mg/m3), MAR2002

OEL-DENMARK: TWA 1000 ppm (1900 mg/m3), MAY2011

OEL-FINLAND: TWA 1000 ppm (1900 mg/m3), STEL 1300 ppm (2500 mg/m3), NOV2011

OEL-FRANCE: VME 1000 ppm (1900 mg/m3), VLE 5000 ppm (9500), FEB2006

OEL-GERMANY: MAK 960 mg/m3 (500 mL/m3), 2005

OEL-HUNGARY: TWA 1900 mg/m3, STEL 7600 mg/m3, SEP2000

OEL-ICELAND: TWA 1000 ppm (1900 mg/m3), NOV2011

OEL-KOREA: TWA 1000 ppm (1900 mg/m3), 2006

OEL-MEXICO: TWA 1000 ppm (1900 mg/m3), 2004

OEL-THE NETHERLANDS: MAC-TGG 1000 mg/m3, 2003

OEL-NEW ZEALAND: TWA 1000 ppm (1880 mg/m3), JAN2002

OEL-NORWAY: TWA 500 ppm (950 mg/m3), JAN1999

OEL-PERU: TWA 1000 ppm (1884 mg/m3), JUL2005

OEL-THE PHILIPPINES: TWA 1000 ppm (1900 mg/m3), JAN1993

OEL-POLAND: MAC(TWA) 1000 mg/m3, MAC(STEL) 3000 mg/m3, JAN1999

OEL-RUSSIA: TWA 1000 mg/m3, STEL 2000 mg/m3, JUN2003

OEL-SWEDEN: TWA 500 ppm (1000 mg/m3);STEL 1000 ppm (1900 mg/m3), JUN2005

OEL-SWITZERLAND: MAK-W 500 ppm (960 mg/m3),KZG-W 1000 ppm (1920 mg/m3), DEC2006

OEL-THAILAND: TWA 1000 ppm (1900 mg/m3), JAN1993

OEL-TURKEY: TWA 1000 ppm (1900 mg/m3), JAN1993

OEL-UNITED KINGDOM: TWA 1000 ppm (1920 mg/m3), OCT2007

OEL IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;

OEL IN SINGAPORE, VIETNAM check ACGIH TLV


NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA

NIOSH Recommended Exposure Level (Rel)
NIOSH REL TO ETHYL ALCOHOL-air:10H TWA 1000 ppm

Reference
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

NIOSH Occupational Exposure Survey Data
NOHS - National Occupational Hazard Survey (1974)
Hazard code: 31500
No. of industries: 430
No. of facilities: 157709 (estimated)
No. of occupations: 242
No. of employees: 2088926 (estimated)
NOES - National Occupational Exposure Survey (1983)
Hazard code: 31500
No. of industries: 334
No. of facilities: 86077 (estimated)
No. of occupations: 222
No. of employees: 2069125 (estimated)
No. of female employees: 1014002 (estimated)


STATUS IN U.S.

EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal

EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; SHE-clonal assay

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo

EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; Mammalian micronucleus

EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test

EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human lymphocytes; In vitro SCE-human

EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman; Sperm morphology-mouse

EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat

EPA TSCA Section 8(b) CHEMICAL INVENTORY

EPA TSCA Section 8(d) unpublished health/safety studies

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

NIOSH Analytical Method, 1994: Ethanol in blood, 8002

NIOSH Analytical Method, 1994: Alcohols I, 1400

NTP Carcinogenesis studies; on test (two year studies), October 2000

OSHA ANALYTICAL METHOD #100


END OF RECORD

RTECS® is provided quarterly by Accelrys, Inc., and was last updated: April, 2012.



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